Research progress of systemic inflammatory markers in retinal vein occlusion
10.3980/j.issn.1672-5123.2026.9.12
- VernacularTitle:全身炎症标志物在视网膜静脉阻塞中的研究进展
- Author:
Qiyang LIN
1
;
Jingwen LIU
1
;
Yijie LU
1
;
Dongcheng LIU
1
;
Bo QIN
1
Author Information
1. Department of Ophthalmology, the Second Clinical Medical College of Jinan University, Shenzhen 518020, Guangdong Province, China; Shenzhen Aier Eye Hospital Affiliated to Jinan University, Shenzhen 518032, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
retinal vein occlusion;
inflammatory markers;
neutrophil-to-lymphocyte ratio;
systemic immune-inflammation index;
platelet-to-lymphocyte ratio
- From:
International Eye Science
2026;26(9):1572-1577
- CountryChina
- Language:Chinese
-
Abstract:
Retinal vein occlusion(RVO), the second most common retinal vascular disease, is primarily caused by thrombosis or mechanical compression from adjacent arteries, leading to partial or complete venous obstruction. Emerging evidence suggests that inflammation plays a pivotal role in the pathogenesis of RVO. Various systemic inflammatory markers, such as NLR, SII, and PLR, have gained increasing attention due to their close association with the occurrence and clinical outcomes of RVO and secondary macular edema. Given their accessibility, low cost, and high reproducibility, these markers can serve as valuable adjuncts to ophthalmic imaging in assessing systemic inflammatory status and disease progression. This review systematically summarizes recent advances in systemic inflammatory markers for RVO, highlighting their associations with the occurrence, prognosis, and treatment response of RVO and macular edema. Furthermore, the limitations of current evidence were evaluated and outline future research directions were discussed, aiming to provide hematological adjunctive evidence for early risk identification and treatment monitoring in RVO.
