Role and research progress of TGF-β and its signaling pathway in scleral remodeling
10.3980/j.issn.1672-5123.2026.9.09
- VernacularTitle:TGF-β及其信号通路在巩膜重塑中的作用及研究进展
- Author:
Wanyue DING
1
;
Wen ZENG
1
;
Liang TANG
1
;
Jingwen FU
1
;
Xin LI
1
;
Chunli SU
1
Author Information
1. Department of Clinic Medicine,Chengdu 610500, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
sclera;
extracellular matrix;
myopia;
transforming growth factor-β(TGF-β);
signaling pathway
- From:
International Eye Science
2026;26(9):1556-1560
- CountryChina
- Language:Chinese
-
Abstract:
The self-remodeling of scleral extracellular matrix(ECM)is a significant characteristic alterationin the development of myopia, and it also influences the progression of myopia. The mechanisms of scleral remodeling are intricate, with transforming growth factor-β(TGF-β)and its associated signaling pathways playing a pivotal role. This review systematically summarizes the major metabolic changes in scleral ECM, the molecular mechanisms of the TGF-β signaling pathway, and its regulatory effects on scleral remodeling during myopic development, aiming to provide new insights and potential strategies for the treatment and prevention of myopia.
