Salviae Miltiorrhizae Radix et Rhizoma and Its Formulas in Treatment of Osteonecrosis of Femoral Head： A Review
10.13422/j.cnki.syfjx.20252497
- VernacularTitle:丹参及其方剂配伍治疗股骨头坏死的研究进展
- Author:
Tao MA
1
;
Yin LI
2
;
Qingsheng XIE
2
;
Haiyang YU
3
;
Xuerui LIU
1
;
Jinqiu WU
1
;
Duoxian WANG
3
;
Hairong HE
1
;
Xiaogang ZHANG
3
Author Information
1. Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730030，China
2. Gansu University of Chinese Medicine，Lanzhou 730030，China
3. Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730030，China
- Publication Type:Journal Article
- Keywords:
osteonecrosis of femoral head;
Salviae Miltiorrhizae Radix et Rhizoma;
active ingredients;
herb pair containing Salviae Miltiorrhizae Radix et Rhizoma;
compound formula containing Salviae Miltiorrhizae Radix et Rhizoma
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(18):335-346
- CountryChina
- Language:Chinese
-
Abstract:
Osteonecrosis of femoral head （ONFH） is a disease that causes osteocyte death due to interruption of blood supply of the femoral head， which may cause symptoms such as joint movement disorders， pain， and even femoral head collapse. Currently， the commonly used methods for treating ONFH in clinical practice are accompanied by problems such as long-term side effects， inaccurate efficacy， technical limitations， and complication risks. Traditional Chinese medicine （TCM） has shown unique advantages of holistic regulation， mild side effects， and symptom alleviation. A review of the related literature shows that Salviae Miltiorrhizae Radix et Rhizoma， as a representative Chinese herbal medicine for activating blood and resolving stasis， has the effects of activating blood， resolving stasis， dredging meridians， and relieving pain. Its active ingredients （such as salvianolic acid B， tanshinone ⅡA， and tanshinone Ⅰ） interfere with bone metabolism balance， osteogenesis and differentiation， and improve bone microcirculation and bone microstructure. Salviae Miltiorrhizae Radix et Rhizoma is often combined with the herbal medicines with the effects of tonifying the liver and spleen or activing blood to form herb pairs （such as Salviae Miltiorrhizae Radix et Rhizoma-Angelicae Sinensis Radix， Salviae Miltiorrhizae Radix et Rhizoma-Chuanxiong Rhizoma， and Salviae Miltiorrhizae Radix et Rhizoma-Drynariae Rhizoma）， which enhances the efficacy through synergistic effects. In the application of TCM compound formulas， Bushen Huoxue prescription， Bushen Huoxue capsules， Gubi Tongxiao granules， and Shenggu Zaizao pills can regulate signaling pathways such as Wnt/β-catenin， Hedgehog， Notch， transforming growth factor（TGF）-β1/Smads， and mitogen-activated protein kinase （MAPK） through multiple targets to significantly improve bone metabolism and hip joint function， playing an important role in preventing and treating ONFH. Through a review of available studies， this paper systematically explains the outstanding advantages of the active ingredients， herb pairs， and compound formulas of Salviae miltiorrhizae Radix et Rhizoma in the prevention and treatment of ONFH. The mechanisms may be related to factors such as promoting osteoblast generation and inhibiting osteoclast formation， increasing osteogenic differentiation， promoting angiogenesis， increasing bone density， inhibiting inflammatory response， and regulating signaling pathways. In the future， modern technology can be employed to optimize dosage forms， and high-quality clinical research should be conducted to further clarify its mechanism of action and promote the precise application of TCM. This review aims to provide more thinking directions for the application of Salviae miltiorrhizae Radix et Rhizoma in preventing and treating ONFH.
