Traditional Chinese Medicine Regulates NF-κB Signaling Pathway in Treating Diabetic Retinopathy： A Review
10.13422/j.cnki.syfjx.20252494
- VernacularTitle:中医药调控NF-κB信号通路干预糖尿病视网膜病变的研究现状
- Author:
Yue ZHU
1
;
Ze WANG
1
;
Yueyao TANG
1
;
Ruoshan GAO
1
;
Xianyan SHEN
1
;
Ruiping XIE
2
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Affiliated Hospital of Gansu University of Chinese Medicine， Lanzhou 730020， China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
nuclear factor （NF）-κB signaling pathways;
diabetic retinopathy （DR）;
research status
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(18):315-324
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy （DR） is a common microvascular complication of diabetes mellitus， and its characteristic pathological changes include microaneurysm formation， hemorrhagic focus formation， exudate deposition， and neovascular proliferation. Long-term hyperglycemic state can induce inflammatory response， oxidative stress， and overexpression of vascular endothelial growth factor （VEGF）， which destroys the blood-retinal barrier and promotes the progression of DR. Although the current clinical treatment methods （such as laser photocoagulation and anti-VEGF drugs） have certain effects， they still have limitations， and there is an urgent need to explore safer and multi-target intervention strategies. Recent studies have discovered that the nuclear factor （NF）-κB signaling pathway plays a key role in the pathological process of DR. This pathway affects the occurrence and development of DR by regulating the release of inflammatory factors， oxidative stress response， and angiogenesis. With the advantages of multi-component， multi-target and overall regulation， traditional Chinese medicine （TCM） has shown unique potential in the prevention and treatment of DR. Especially， its precise regulation of the NF-κB pathway has become a research hotspot. This article systematically reviews the mechanisms of action of NF-κB-related signaling pathways in DR， with focuses on the research progress in TCM single herbs and active ingredients， Chinese patent medicines， and TCM compound preparations in ameliorating DR by regulating the NF-κB pathway. This review aims to provide a theoretical basis and a transformation direction for the development of drugs for the prevention and treatment of DR.
