Chinese Medicine against Parkinson's Disease Based on Microbiota-Gut-Brain Axis Theory： A Review
10.13422/j.cnki.syfjx.20260236
- VernacularTitle:基于“微生物-肠-脑轴”理论探讨中药治疗帕金森病的研究进展
- Author:
Xin GAO
1
;
Chen LIU
2
;
Dapeng TONG
2
;
Shumin LIU
2
Author Information
1. Heilongjiang Shenzhi Hospital， Harbin 150040， China
2. Heilongjiang University of Chinese Medicine， Harbin 150040， China
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
microbiota-gut-brain axis;
Chinese medicine intervention;
gut microbiota
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(18):307-314
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease （PD）， with its incidence increasing year by year and its onset age gradually becoming younger， has become a major chronic multisystem movement disorder that threatens public health. The microbiota-gut-brain axis （MGBA） is a bidirectional communication system connecting the enteric nervous system and the central nervous system. Its core functions rely on the synergistic interactions among gut microbiota， neural signal transmission， endocrine regulation， and immune interactions， and it plays an indispensable role in maintaining gut-brain dynamic homeostasis， regulating neurotransmitter metabolism， and modulating inflammatory responses. Current studies have found that the gut microbiota of patients with PD exhibits dual dysbiosis characterized by the enrichment of opportunistic pathogens and beneficial bacteria， accompanied by abnormal metabolite levels， which accumulate and trigger neuroinflammation， demonstrating the pivotal regulatory role of the MGBA in the early pathology of PD. Furthermore， this article summarizes Chinese medicines， their active components， and compound formulas that may prevent and treat PD through intervention in the MGBA. These agents can modulate microbial composition， suppress inflammation and oxidative stress， protect the intestinal barrier， and ameliorate dopaminergic neuron damage. By systematically summarizing the central mechanisms of the MGBA in PD and reviewing the research progress of traditional Chinese medicine （TCM） mediated regulation of this pathway in PD intervention， this article aims to provide a theoretical reference for the clinical prevention and treatment of PD and scientific research design.
