Mechanism of Traditional Chinese Medicine in Treatment of Metabolic Dysfunction-associated Fatty Liver Disease： A Review
10.13422/j.cnki.syfjx.20251529
- VernacularTitle:中医药治疗代谢相关脂肪性肝病的作用机制及研究进展
- Author:
Shuangmei ZHAO
1
;
Hong WANG
1
;
Suying WANG
2
;
Jiale MA
1
;
Long PENG
1
;
Hengyu ZHANG
1
;
Dewen LIANG
1
;
Wang GAO
1
;
Huizhen LI
1
Author Information
1. Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM）， Tianjin 300250， China
2. Tianjin University of TCM， Tianjin 301617， China
- Publication Type:Journal Article
- Keywords:
metabolic dysfunction-associated fatty liver disease;
mechanism of action;
traditional Chinese medicine;
research progress;
pathogenesis;
signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(18):282-291
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic dysfunction-associated fatty liver disease （MAFLD） is a chronic liver disease closely related to metabolic dysfunction. Its global prevalence is increasing year by year and shows a trend toward younger onset. It is closely associated with cardiovascular and cerebrovascular diseases， chronic kidney disease， and extrahepatic malignant tumors， and has become a major public health problem affecting the health of the Chinese population. At present， the treatment of MAFLD mainly focuses on lifestyle intervention. When metabolic cardiovascular risk factors and liver injury are present， pharmacological intervention is required. However， there is still no specific drug therapy for MAFLD. In recent years， many studies have found that the pathogenesis of MAFLD involves interactions among multiple factors， including insulin resistance， oxidative stress， endoplasmic reticulum stress， programmed cell death， immune dysregulation， inflammasomes， gut microbiota imbalance， and bile acid metabolism. Traditional Chinese medicine （TCM） has advantages in integrated regulation with multiple components and multiple targets， and shows significant efficacy in the treatment of MAFLD. Active components of Chinese medicinal herbs and Chinese medicine compound formulas exert definite therapeutic effects by regulating multiple signaling pathways to improve lipid metabolism disorders， inhibit inflammatory responses， and regulate the gut microbiota， thereby effectively improving clinical symptoms and delaying the occurrence and development of MAFLD. Therefore， strengthening research on the mechanisms of action of TCM in MAFLD is of crucial importance and significance for its treatment. This article summarizes the mechanisms by which Chinese medicine monomers and compound formulas intervene in MAFLD through the regulation of related signaling pathways， based on the retrieval and analysis of relevant literature from multiple databases， with the aim of providing theoretical support and a reference basis for the clinical application of TCM in the treatment of MAFLD.
