Astragali Radix and Its Formulas in Treatment of Diabetic Cardiomyopathy： A Review
10.13422/j.cnki.syfjx.20252503
- VernacularTitle:黄芪及其方剂配伍治疗糖尿病心肌病的研究进展
- Author:
Ran CUI
1
;
Linping ZHU
2
;
Jingshun YAN
3
;
Pingting ZHANG
1
;
Chuxuan XIE
1
;
Yansong LIU
1
;
Mei ZHAO
2
;
Yuhong LI
4
Author Information
1. Graduate School， Tianjin University of Traditional Chinese Medicine（TCM），Tianjin 301617， China
2. The Second Affiliated Hospital of Tianjin University of TCM，Tianjin 300150，China
3. First Teaching Hospital of Tianjin University of TCM，Tianjin 300381，China
4. State Key Laboratory of Component-based Chinese Medicine， Institute of TCM， Tianjin University of TCM， Tianjin 301617， China
- Publication Type:Journal Article
- Keywords:
Astragali Radix;
Astragali Radix polysaccharides;
astragaloside Ⅳ;
diabetic cardiomyopathy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(18):248-259
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy （DCM） is a common chronic complication of diabetes， categorized as consumptive thirst in traditional Chinese medicine （TCM）， and it subsequently gives rise to chest impediment. DCM is characterized by a complex pathogenesis and exhibits long-term progression with poor prognosis in clinical practice. Astragali Radix， as a medicinal material with edible value， possesses diverse active components including saponins， polysaccharides， and flavonoids. It has the effects of tonifying Qi， elevating Yang， promoting fluid production， nourishing blood， expressing toxin， and expelling pus. Modern pharmacological studies have confirmed that Astragali Radix and its active components exert therapeutic effects in various aspects such as inhibition of inflammation， alleviation of stress injury， regulation of programmed cell death， modulation of glucose and lipid metabolism， inhibition of myocardial fibrosis， and regulation of gut microbiota and metabolites， treating DCM in a multi-component， multi-target， and multi-pathway manner. The compatibility of Astragali Radix exerts both synergistic and antagonistic effects. The compound preparations and extracts of Astragali Radix are widely used in clinical practice， and the development of novel nano and gel materials and extracellular vesicles helps to improve the oral bioavailability， providing more possibilities for the clinical application of Astragali Radix in DCM， though its potential for clinical translation requires ongoing exploration. This review summarizes the TCM theoretical basis of Astragali Radix in the treatment of DCM， and integrates modern pharmacological research results to delve into the effects and mechanisms of the herb combinations， compound preparations， extracts， and new composite materials of Astragali Radix in the treatment of DCM， aiming to provide a reference for in-depth research and new drug development of Astragali Radix for DCM.
