Modern Clinical Application and Mechanism of Action of Sanhuang Xiexintang： A Review
10.13422/j.cnki.syfjx.20252196
- VernacularTitle:三黄泻心汤现代临床应用与作用机制研究进展
- Author:
Zhiyi WANG
1
;
Wenlong YANG
1
;
Ming BAI
1
;
Zibo LI
1
;
Erping XU
1
Author Information
1. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao，Henan Province， Academy of Chinese Medical Sciences， Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Review
- Keywords:
Sanhuang Xiexintang;
chemical composition;
clinical application;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(18):237-247
- CountryChina
- Language:Chinese
-
Abstract:
Sanhuang Xiexintang （SHXXT）， originating from the Synopsis of the Golden Chamber （Jin Gui Yao Lue）， comprises three medicinal herbs： Rhei Radix et Rhizoma， Coptidis Rhizoma， and Scutellariae Radix. Renowned for its effects of purging fire， detoxifying， drying dampness， and draining heat， SHXXT primarily treats syndromes characterized by internal excess heat， dampness-heat stagnation， and reckless blood movement due to heat. Because of the concise formulation and remarkable efficacy of this formula， modern research has extensively explored the chemical composition， clinical applications， and pharmacological mechanisms of SHXXT， yielding significant advancements. As a modern derivative of SHXXT， Yiqing granules exemplify the transformation of classical formulas into convenient and precise applications， embodying the paradigm of modern development of classical formulas. This systematic review synthesizes recent research progress in SHXXT. Chemical analyses reveal that the active components—anthraquinones， alkaloids， and flavonoids—of SHXXT exert holistic therapeutic effects through multi-component synergy. Clinical studies demonstrate broad utility of this formula in managing digestive disorders， endocrine diseases， urinary tract infections， dermatological conditions， and systemic inflammatory diseases， highlighting its multi-system regulatory potential. Mechanism investigations elucidate its multi-target mechanism of action， including antimicrobial， anti-inflammatory， metabolic-regulatory， hepatoprotective， and gastrointestinal-modulating effects， reflecting an integrated multi-component， multi-target， multi-pathway mode of action. This review systematically summarizes the modern research progress in SHXXT， providing a theoretical foundation for deciphering the scientific essence of classical formulas and advancing their precision application in clinical practice.
