Clinical Application and Mechanism Insights of Xiaoyao San in Treating Ophthalmic Disorders From Theory of Treating Different Diseases with Same Method
10.13422/j.cnki.syfjx.20260399
- VernacularTitle:基于“异病同治”理论探讨逍遥散在眼病中的临床应用与作用机制
- Author:
Fang YANG
1
;
Jingsheng YU
2
Author Information
1. Hunan University of Chinese Medicine， Changsha 410208， China
2. The First Hospital of Hunan University of Chinese Medicine， Changsha 410000， China
- Publication Type:Journal Article
- Keywords:
Xiaoyao San;
treating different diseases with the same method;
ophthalmic diseases;
clinical application;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(18):227-236
- CountryChina
- Language:Chinese
-
Abstract:
Xiaoyao San， first recorded in Taiping Huimin Hejiju Fang， has the traditional functions of soothing the liver， relieving constraint， strengthening the spleen， nourishing blood， and regulating Qi movement. Although its applications in gynecological and emotional disorders have been extensively studied， its clinical use， pattern differentiation， and mechanisms in ophthalmology have not been systematically reviewed. Despite the diversity of ophthalmic diseases and their clinical manifestations， the frequent use of Xiaoyao San reflects the traditional Chinese medicine principle of "treating different diseases with the same method" by targeting shared pathogenesis and core syndromes. Modern studies suggest that its mechanisms may involve modulation of immune and inflammatory responses， attenuation of oxidative stress， protection of retinal ganglion cells and the blood-retinal barrier， improvement of ocular microcirculation， inhibition of pathological neovascularization， and regulation of neuroendocrine function， apoptosis， and cell proliferation. Guided by the theory of "treating different diseases with the same method"， this review systematically examines the historical origin， formula modifications， and classical records of Xiaoyao San， and integrates modern literature and representative medical cases to summarize its clinical applications and mechanisms in ocular surface diseases， central serous chorioretinopathy， diabetic retinopathy， optic neuropathies， retinal vascular occlusive diseases， dry eye， thyroid-associated ophthalmopathy， and glaucoma. This review aims to clarify the theoretical basis for its differentiated use in ophthalmology and to provide a foundation for its standardized clinical application.
