Effect of Anzi Tiaochong Decoction Combined with Aspirin on Peripheral Blood CD19+CD24hiCD27+ Regulatory B Cells in Patients with Obstetric Antiphospholipid Syndrome （Pattern of Kidney Deficiency and Blood Stasis）
10.13422/j.cnki.syfjx.20260398
- VernacularTitle:安子调冲汤联合阿司匹林对肾虚血瘀型产科抗磷脂综合征患者外周血CD19+CD24hiCD27+调节性B细胞的影响
- Author:
Yan CHEN
1
;
Jia LI
1
;
Suning HUANG
2
;
Ying ZHAO
2
;
Yan NING
1
Author Information
1. Shenzhen Maternity and Child Healthcare Hospital， Women and Children's Medical Center， Southern Medical University，Shenzhen 518000， China
2. Guangzhou University of Chinese Medicine，Guangzhou 510000， China
- Publication Type:Journal Article
- Keywords:
obstetric antiphospholipid syndrome;
Anzi Tiaochong decoction;
pattern of kidney deficiency and blood stasis;
regulatory B cells
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(18):189-196
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical efficacy of Anzi Tiaochong decoction combined with aspirin and the effects of this therapy on the peripheral blood phospholipid antibody titers， coagulation function， and CD19+CD24hiCD27+regulatory B （Breg） cells in patients with obstetric antiphospholipid syndrome （OAPS） （pattern of kidney deficiency and blood stasis）. MethodsPatients who meet the inclusion criteria were randomly allocated into an observation group （50 patients， with 4 patients dropped out and 46 patients completed） and a control group （50 patients， with 2 patients dropped out， 1 patient excluded， and 47 patients completed） through a random number table method. The control group was treated with aspirin enteric-coated tablets， 75 mg/time， once a day， and the observation group with Anzi Tiaochong decoction， 1 bag/day on the basis of the therapy in the control group. The treatment course for both groups was 8 weeks， and the patients were followed up for 4 weeks. The traditional Chinese medicine （TCM） symptom scores， titers of peripheral blood phospholipid antibodies ［anti-cardiolipin antibody IgM （ACA IgM）， anti-cardiolipin antibody IgG （ACA IgG）， anti-β2-glycoprotein 1 antibody IgM （β2GP1-IgM）， and anti-β2-glycoprotein 1 antibody IgG （β2GP1-IgG）］， D-dimer （D-D）， thromboelastography parameters ［clotting factor activity （R）， platelet function maximum amplitude （MA）， coagulation composite index （CI）， and clot strength （G）］， CD19+CD24hiCD27+ Breg expression rate， and adverse drug reactions were recorded for the two groups before and after treatment. ResultsAfter treatment， both groups showed decreased ACA IgM， ACA IgG， β2GP1-IgM， β2GP1-IgG， D-D， MA， and G （P<0.05） and increased R （P<0.05）. There was no statistically significant difference in CI. Compared with the control group， the observation group showed more significant decreases in TCM symptom scores and phospholipid antibody titers （P<0.05）. After treatment， the expression rate of Breg in the observation group was higher than that before treatment （P<0.05）.There was no significant difference in Breg expression rate before and after treatment in the control group. Neither group experienced significant adverse reactions. ConclusionAnzi Tiaochong decoction combined with aspirin can alleviate the symptoms， reduce the phospholipid antibody titers， and restore the coagulation status of patients with obstetric antiphospholipid syndrome （pattern kidney deficiency and blood stasis）. It may exert the therapeutic effects by regulating Breg to maintain the patient's immune balance.
