Clinical Observation of Juanyin Xiefei Prescription Combined with Continuous Positive Airway Pressure for Moderate-to-severe Obstructive Sleep Apnea-hypopnea Syndrome with Phlegm-dampness Obstruction Pattern
10.13422/j.cnki.syfjx.20251424
- VernacularTitle:蠲饮泄肺方联合持续正压通气治疗中/重度阻塞性睡眠呼吸暂停低通气综合征痰湿内阻证的临床观察
- Author:
Min YE
1
;
Jie TANG
1
;
Qingqi WANG
2
Author Information
1. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine，Shanghai University of Traditional Chinese Medicine（TCM）， Shanghai 200437，China
2. Shanghai University of TCM，Shanghai 200437，China
- Publication Type:Journal Article
- Keywords:
obstructive sleep apnea-hypopnea syndrome;
Juanyin Xiefei prescription;
phlegm-dampness obstruction syndrome;
"Yang transforming Qi while Yin constituting form";
Fanji Nicong method
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(18):171-180
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveBased on the theory of "Yang transforming Qi while Yin constituting form"， this study aimed to evaluate the clinical efficacy and safety of Juanyin Xiefei prescription combined with noninvasive ventilation in patients with moderate-to-severe obstructive sleep apnea-hypopnea syndrome （OSAHS） with the phlegm-dampness obstruction pattern. MethodsA total of 84 patients with moderate-to-severe OSAHS with the phlegm-dampness obstruction pattern were enrolled and randomly assigned to a treatment group （42 cases） and a control group （42 cases）. The control group received noninvasive ventilation combined with lifestyle intervention， while the treatment group received Juanyin Xiefei prescription in addition to the same regimen. The treatment course lasted 8 weeks. The apnea-hypopnea index （AHI）， lowest oxygen saturation （LSpO2）， Epworth Sleepiness Scale （ESS） score， traditional Chinese medicine （TCM） syndrome scores， and serum levels of interleukin-6 （IL-6）， tumor necrosis factor-α （TNF-α）， superoxide dismutase （SOD）， and testosterone were measured before and after treatment and statistically analyzed. ResultsTwo cases were lost to follow-up in each group. Thus， 40 patients in the treatment group and 40 in the control group were included in the final analysis. There were no significant differences between the two groups in sex， age， disease duration， or comorbidities at baseline， indicating comparability. Compared with pre-treatment levels， AHI， ESS scores， IL-6， and TNF-α were significantly reduced in both groups， while LSpO2， SOD activity， and serum testosterone levels were significantly increased （P<0.01）. In the control group， TCM primary syndrome scores， partial secondary syndrome scores， and total TCM syndrome scores were significantly reduced （P<0.05）， whereas the improvement in the secondary symptom of "dry mouth without desire to drink" was not statistically significant. In the treatment group， all TCM syndrome scores were significantly reduced （P<0.05）. After treatment， compared with the control group， the treatment group showed more significant improvements in AHI， LSpO2， ESS scores， and SOD activity （P<0.01）， whereas there were no significant differences between groups in IL-6， TNF-α， or serum testosterone. The improvements in all TCM syndrome scores were more pronounced in the treatment group （P<0.05）. In the control group， there were 1 case of clinical control， 13 markedly effective， 15 effective， and 11 ineffective cases， with a total effective rate of 72.5%. In the treatment group， there were 3 cases of clinical control， 24 markedly effective， 8 effective， and 5 ineffective cases， with a total effective rate of 87.5%. The difference in overall efficacy between the two groups was statistically significant （χ2=8.651，P<0.05）. No serious adverse events were observed in either group during treatment. ConclusionGuided by the theory of "Yang transforming Qi while Yin constituting form"， the application of Juanyin Xiefei prescription combined with noninvasive ventilation in patients with moderate-to-severe OSAHS with the phlegm-dampness obstruction pattern can significantly reduce AHI and improve airway obstruction and nocturnal hypoxia， while alleviating TCM symptoms such as snoring， apnea， and nocturnal suffocation caused by phlegm-dampness obstruction. The therapeutic mechanism may be related to regulating Yin-Yang dynamics to resolve phlegm and remove stasis， as well as modulating oxidative stress to attenuate pathological injury.
