Progress of researches on techniques for molecular detection of Clonorchis sinensis infections
10.16250/j.32.1915.2024217
- VernacularTitle:华支睾吸虫感染分子检测技术研究进展
- Author:
Binbin XIE
1
;
Yunhai GUO
2
;
Xiaonen WU
1
;
Zhiying HOU
1
;
Yang HONG
2
;
Tian TIAN
2
;
Xiaonong ZHOU
3
;
Junhu CHEN
2
Author Information
1. Hainan Tropical Diseases Research Center (Hainan Sub-Center, Chinese Center for Tropical Diseases Research), Haikou, Hainan 570203, China
2. National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China
3. Hainan Tropical Diseases Research Center (Hainan Sub-Center, Chinese Center for Tropical Diseases Research), Haikou, Hainan 570203, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China
- Publication Type:Journal Article
- Keywords:
Clonorchis sinensis;
Clonorchiasis;
Molecular diagnosis;
Detection technology
- From:
Chinese Journal of Schistosomiasis Control
2026;38(3):323-329
- CountryChina
- Language:Chinese
-
Abstract:
Clonorchis sinensis primarily lives in the host liver and biliary system, leading to serious health issues, such as hepatobiliary lesions and cholangiocarcinoma. Establishment of rapid, sensitive and specific tools is of great significance for early diagnosis and management of clonorchiasis. Recently, molecular biological techniques have been widely used for detection of C. sinensis infections. This review summarizes the advances in the major molecular assays for detection of C. sinensis infections in intermediate and definite hosts, including PCR, loop-mediated isothermal amplification, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins system, and high-throughput sequencing, and summarizes the characteristics and application prospects of these assays, so as to provide precision detection and management of C. sinensis infection.
