Pathogenesis and Treatment Strategies of Colorectal Cancer Mediated by Circadian Rhythm Disorder：from the Perspective of Traditional Chinese Medicine Chronomedicine
10.13288/j.11-2166/r.2026.16.018
- VernacularTitle:中医时间医学视角下昼夜节律紊乱介导结直肠癌的发病机制及治疗策略
- Author:
Zhenming XIE
1
;
Wenqi HUANG
1
;
Wenyu WU
2
;
Huibin CHEN
1
;
Bing YANG
1
;
Dongxin TANG
1
Author Information
1. Guizhou University of Traditional Chinese Medicine，Guiyang，550025
2. The First Affiliated Hospital of Guizhou University of TCM
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
chronomedicine;
circadian rhythm
- From:
Journal of Traditional Chinese Medicine
2026;67(16):1798-1803
- CountryChina
- Language:Chinese
-
Abstract:
Based on the theory of traditional Chinese medicine （TCM） chronomedicine， this paper explores the pathogenesis and treatment strategies of colorectal cancer mediated by circadian rhythm disorders. It is believed that the imbalance of yin and yang is isomorphic to the disorder of biological clock genes， which is the root cause of the disease. The disharmony of ying and wei （营卫） corresponds to the imbalance of immunity and metabolism， which is the pivot of the disease. The disorder of qi movement is related to the imbalance of intestinal barrier， which is the manifestation of the disease. Accordingly， relevant strategies are proposed， including chronochemotherapy regimen that aligns with biological rhythms to enhance efficacy and reduce toxicity， acupuncture based on the ebb and flow of midnight and midday which selects acupoints along meridians to harmonize qi and blood， and a timed medication strategy that matches the disease mechanism by administering drugs at optimal times. These strategies aim to deepen the understanding of the pathogenesis of colorectal cancer mediated by circadian rhythm disorders from the perspective of TCM chronomedicine， thereby providing new ideas for clinical practice.
