Efficacy of intravaginal hydrogen peroxide in the management of bacterial vaginosis among premenopausal non-pregnant women seen at the outpatient department of a tertiary hospital: A randomized controlled trial.
- Author:
Mariemids S. ISIDRO
;
Lylah REYES
;
Jennifer T. CO
- Publication Type:Journal Article, Original
- MeSH: Human; Female; Adult; Adolescent; Vaginosis, Bacterial; Metronidazole; Hydrogen Peroxide; Lactobacillus; Tritium; Hydrogen; Bacterial Load; Odorants; Gram's Stain; Gentian Violet; Phenazines; Vaginal Discharge
- From: Philippine Journal of Obstetrics and Gynecology 2012;36(2):65-71
- CountryPhilippines
-
Abstract:
BACKGROUND: The standard treatment for bacterial vaginosis is metronidazole. But it is less tolerable for some patients. Hence, the search for treatment with less unwanted effects is warranted.
OBJECTIVE: To determine the efficacy of intravaginal hydrogen peroxide (H202) as alternative treatment of bacterial vaginosis
METHODS: Included were 82 non-pregnant, and non-lactating women 15 to 42 years old with bacterial vaginosis. Group A received 30-ml of 3% hydrogen peroxide intravaginally once-daily while control group B had 500-mg metronidazole tablet orally twice a day. Both completed for 7 days. The estimated gram-negative coccobacilli and lactobacilli count through gram stain, the amount and odor of the vaginal discharge were then assessed before and after treatment.
RESULTS: Only 36% (15/41) of those in the H202 arm had gram-negative coccobacilli count of less than 10/hpf as compared to 87% (36/41) among those in the control (P