The use of luteal phase support in In-vitro fertilization: Experience of a private infertility center in 2005 - 2008.
- Author:
Susana S LAO
;
Ma Trinidad R VERA
- Publication Type:Journal Article, Original
- MeSH:
Human;
Female;
X
- From:
Philippine Journal of Obstetrics and Gynecology
2010;34(1):15-22
- CountryPhilippines
-
Abstract:
Objectives: To describe the experience of the Center for Reproductive Medicine in the use of luteal phase support protocols in in-vitro fertilization (2005 - 2008).Design: A retrospective cohort study of couples undergoing in vitro fertilization using the different modalities of luteal phase support from 2005 to 2008 at CRM.Main outcome measure(s): clinical pregnancy rate. miscarriage rate and live birthrate.Result(s): From 2005 - 2008, 94 patients underwent in vitro fertilization.The center achieved a 36% clinical pregnancy rate, and 27.6% live birthrate. The most common luteal phase used was a combination of progesterone, estradiol and aspirin which achieved a 39% clinical pregnancy rate and a 28% live birthrate. The luteal phase support protocol which obtained the highest clinical pregnancy rate of 50% was that of progesterone alone which resulted in 50% live birthrate. But it did not reach clinical significance as compared to the other protocols (P>0.05). The use of the intramuscular (IM) progesterone showed a significant P value, with an odds ratio of 3.83, suggesting that it can increase the likehood of clinical pregnancy by as much as 4x.Conclusion(s): The most common luteal phase support protocol used was a combinatiion of progesterone and aspirin. Progesterone alone protocol achieved the highest clinical pregnancy rate of 50% which all resulted in live birht. Among the different types and routes of progesterone used, only the IM progesterone was shown to be clinically significant in increasing the pregnancy rate.
