Candidatus laris kella arthropodarum, an intra-mitochondrial alpha-proteobacterium detected in Ixodes persulcatus in China
10.3969/j.issn.1005-0507.2025.04.003
- VernacularTitle:节肢动物线原体———一种在全沟硬蜱中检测到的线粒体内共生菌
- Author:
Hao FENG
1
;
Zhi-tong LIU
2
;
Tong QIN
3
;
Yi SUN
1
Author Information
1. State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China
2. State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China; School of Basic Medicine, Guizhou Medical University, Guiyang 561113, China
3. Medical Crops, Navay Logistics Academy, PLA, Beijing, China
- Publication Type:Journal Article
- Keywords:
Candidatus Lariskella arthropodarum;
Midichloriaceae;
Ixodes persulcatus;
China
- From:
Acta Parasitologica et Medica Entomologica Sinica
2025;32(4):210-218
- CountryChina
- Language:Chinese
-
Abstract:
Objective Candidatus Lariskella arthropodarum' (CLA) is a novel intracellular alpha-proteobacterium closely related to Candidatus Midichloria mitochondrii'(CMM), notable for its unique ability to invade and destroy mitochondria within host germline cells. CLA has been proposed as a potential pathogen, as it has occasionally been detected in blood samples from both humans and other vertebrates. However, the mechanisms of CLA infection and transmission remain poorly understood. Methods Natural CLA infection in unfed Ixodes persulcatus was investigated using meta-transcriptomic analysis of specimens collected from Zhalantun City, Hulunbuir League, Inner Mongolia Autonomous Region(IMAR), China. Results The top-matching transcript assembly was 21 917 base pairs in length and encoded genes including ccmA, mrdA, lon, ppsC, prmC, ileS, gshB, gmk, rpoC, and rpoB, all identical to CLA. These findings were further confirmed by amplification of 16S rRNA fragments(99.72% identity to CLA; GenBank accession number AB906829.1)from the DNA of the same tick specimens. A sex-biased prevalence of CLA was observed in I. persulcatus, with significantly higher infection rates in females(83.05%)compared to nymphs(46.11%)and males (36.47%). Conclusions This suggests differential adaptation of CLA across tick sexes and developmental stages.
