A 21-year old commercial sex worker, G2P1(0101) presented at 20·21 weeks of gestation with a rapidly enlarging infected cauliflower-like vulvar mass. Infection and anemia were managed and followed by surgical excision of the vulvar mass. One week postoperatively, intrauterine fetal demise occurred and the patient delivered spontaneously after 2 weeks (beginning tumor regrowth was seen at this time). Preliminary histopathologic findings showed Condyloma acuminata and treatment with an immune modifier cream was started but there was no response. Further evaluation of histopathologic result led to the final diagnosis of giant Condyloma acuminata of Buschke and Lowenstein/Verrucous carcinoma. There was rapid enlargement of the tumor in six weeks, despite medical treatment, with enlargement of bilateral inguinal lymph nodes. A radical vulvectomy with bilateral groin node dissection was done.This successfully treated the tumor with no recurrence on her 6th month follow up.