NATURAL PRODUCTS TARGETING NITRIC OXIDE AS A THERAPEUTIC STRATEGY FOR TREATMENT OF HYPERTENSION: A REVIEW

Norasikin Ab Azis; Effendi Ibrahim; Harbindarjeet Singh; Harbindarjeet Singh; Wu Yuan Seng; Wu Yuan Seng; Nor Hisam Zamakshshari; Srinivasa Rao Sirasanagandla; Choy Ker Woon; Choy Ker Woon

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NATURAL PRODUCTS TARGETING NITRIC OXIDE AS A THERAPEUTIC STRATEGY FOR TREATMENT OF HYPERTENSION: A REVIEW

Author: Norasikin Ab Azis ¹ ; Effendi Ibrahim ² ; Harbindarjeet Singh ² ; Harbindarjeet Singh ³ ; Wu Yuan Seng ⁴ ; Wu Yuan Seng ⁵ ; Nor Hisam Zamakshshari ⁶ ; Srinivasa Rao Sirasanagandla ⁷ ; Choy Ker Woon ⁸ ; Choy Ker Woon ⁹
Author Information

1. Department of Pharmacology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia.
2. Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia
3. Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Sg Buloh, Selangor Malaysia
4. Sunway Microbiome Centre, School of Medical and Life Sciences, Sunway University, Subang Jaya, 47500 Selangor, Malaysia.
5. Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Subang Jaya, 47500 Selangor, Malaysia.
6. Department of Chemistry, Faculty of Resources Science and Technology, University Malaysia Sarawak, Kota Samarahan, 94300 Kuching, Sarawak, Malaysia.
7. Department of Human & Clinical Anatomy, College of Medicine & Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al-Khoud, Muscat, Oman.
8. Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Sg Buloh, Selangor Malaysia.
9. Department of Anatomy, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia
Publication Type:Journal Article
Keywords: Natural products; Hypertension; Antihypertensive; Nitric Oxide signalling
From: Journal of University of Malaya Medical Centre 2025;28(1):9-23
CountryMalaysia
Language:English
Abstract: NATURAL PRODUCTS TARGETING NITRIC OXIDE AS A THERAPEUTIC STRATEGY FOR TREATMENT OF HYPERTENSION: A REVIEW:Hypertension remains a significant global health challenge, necessitating the exploration of novel therapeutic strategies. Nitric oxide (NO) signaling plays a pivotal role in blood pressure regulation, making it an attractive target for hypertension management. Natural products have garnered considerable attention for their potential to modulate NO signaling pathways and mitigate hypertension. This review provides a comprehensive overview of natural products targeting NO as a therapeutic strategy for hypertension treatment. We systematically examine the mechanisms by which natural compounds enhance NO bioavailability, promote vasodilation, and exert antihypertensive effects. Key natural products are evaluated for their efficacy in preclinical studies. Furthermore, we discuss the challenges and limitations associated with translating preclinical findings to clinical practice. Overall, this review highlights the promising role of natural products in modulating NO signaling pathways and offers insights into their potential as adjunctive therapies for hypertension management. Further research is warranted to elucidate the optimal dosing regimens, long-term effects, and potential drug interactions of natural compounds in diverse patient populations.
Full text:2026081917024711647NATURAL PRODUCTS.pdf