Stevens-Johnson syndrome (SJS) is a life-threatening condition affecting the skin in which cell death causes the epidermis to separate from the dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. The causes include medications, infections, rarely cancers, but majority are idiopathic. We report a case of a 20-year-old man who presented with multiple erythematous papules some coalescing to form plaques over the face, neck, trunk, back, both upper and lower extremities after nevirapine intake. The patient was treated with systemic corticosteroids, which were tapered gradually affording resolution.