Research Progress of DNA Methylation in Gastric Cancer

Rui WU; Yuyu LIN; Qiangqiang TIAN; Yishudong LI; Ya ZHENG; Zhaofeng CHEN

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Research Progress of DNA Methylation in Gastric Cancer

VernacularTitle:DNA甲基化在胃癌中的作用研究进展
Author: Rui WU ¹ ; Yuyu LIN ¹ ; Qiangqiang TIAN ¹ ; Yishudong LI ¹ ; Ya ZHENG ² ; Zhaofeng CHEN ³
Author Information

1. Lanzhou University, The First Clinical Medical School, Lanzhou 730000, China;Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China;Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730000, China;
2. Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China;Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730000, China;
3. Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China;Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730000, China;Digestive Endoscope Center, the First Hospital of Lanzhou University, Lanzhou 730000, China;
Publication Type:Review
Keywords: gastric cancer; DNA methylation; early diagnosis; targeted therapy; prognosis
From: Medical Journal of Peking Union Medical College Hospital 2025;17(4):1117-1125
CountryChina
Language:Chinese
Abstract:
In recent years, numerous studies have elucidated the correlation between DNA methylation and gastric cancer (GC) from the perspectives of early diagnosis, targeted therapy, and prognosis assessment. However, the clinical understanding of their relationship remains incomplete and insufficiently explored. This review will summarize the research progress on the role of DNA methylation in GC, focusing on methylation biomarkers currently approved for GC detection, DNA methylation-based diagnostic markers utilizing liquid biopsy techniques, as well as the relationship between DNA methylation and GC treatment and prognosis. The aim is to provide further insights for the clinical diagnosis and treatment of GC.