Pathogenesis Evolution Characteristics and Intervention Strategies for Alternation Between Active and Remission Phases of Inflammatory Bowel Disease：Based on the Theory of "Grease-Turbidity-Heat Toxin"
10.13288/j.11-2166/r.2026.15.014
- VernacularTitle:炎症性肠病活动-缓解交替的“膏-浊-热毒”病机演变特点及干预策略
- Author:
Ting ZHENG
1
;
Kaiyue HUANG
1
;
Jiayan LI
1
;
Fengyun WANG
1
;
Xyudong TANG
1
;
Lin LYU
1
Author Information
1. Institute of Spleen and Stomach Diseases，Xiyuan Hospital，China Academy of Chinese Medical Sciences，Beijing，100091
- Publication Type:Journal Article
- Keywords:
inflammatory bowel disease;
grease turbidity;
heat toxin;
pathological evolution
- From:
Journal of Traditional Chinese Medicine
2026;67(15):1664-1668
- CountryChina
- Language:Chinese
-
Abstract:
Based on the theoretical framework of "grease-turbidity-heat toxin"， this paper elucidates the patholo-gical evolution pattern underlying the alternation between active and remission phases of inflammatory bowel disease （IBD）. It is proposed that the active phase of IBD represents a progressive and explosive process characterized by internal accumulation of grease turbidity， constraint transforming into heat， and exuberant heat generating toxin. During the remission phase， the pathogenic process manifests as subsidence of heat toxin， depletion of qi and yin， latent retention of residual turbidity， and a state of coexistence between deficiency of healthy qi and lingering pathogenic factors. Accordingly， a staged therapeutic strategy with dynamic intervention and targeted modulation has been established. During the active phase， treatment follows the sequential principle of unblocking， clearing， and resolving pathogenic factors. In the early stage， the therapeutic approach focuses on regulating qi movement， fortifying the spleen， and resolving turbidity， using Tongxie Essential Formula （痛泻要方） and Shenling Baizhu Powder （参苓白术散） to regulate qi and fortify spleen. In the middle stage， the strategy emphasizes clearing heat， eliminating dampness， and dispersing pathogenic accumulation through downward and outward pathways， and Gegen Qinlian Decoction （葛根芩连汤） combined with Banxia Xiexin Decoction （半夏泻心汤） is used to clear and resolve damp-heat. In the late stage， treatment aims to resolve toxin， restrain sore， cool blood， and stabilize collaterals， using Baitouweng Decoction （白头翁汤）， Shaoyao Decoction （芍药汤）， and Xijiao Dihuang Decoction （犀角地黄汤） to eliminate toxins and cool blood. During the remission phase， the principle of reinforcing， consolidating， and penetrating is adopted to restore internal balance and clear the source， using Sishen Pills （四神丸） and Sijunzi Decoction （四君子汤） to reinforce healthy qi and venting pathogens.
