ZHANG Zhen's Experience in Treating Rheumatoid Arthritis Complicated with Anemia Using Modified Yisui Shengxue Decoction （益髓生血汤）
10.13288/j.11-2166/r.2026.15.003
- VernacularTitle:张震运用益髓生血汤加减治疗类风湿关节炎合并贫血经验
- Author:
Jianping ZHU
1
;
Yuyao YANG
1
;
Wenhui ZHU
2
;
Tianwu ZHANG
1
Author Information
1. Hospital of Traditional Chinese Medicine of Pu'er City，Yunnan Province，665000
2. Second Clinical Medical College，Zhejiang Chinese Medical University
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
anemia;
Yisui Shengxue Decoction （益髓生血汤）;
experience of famous doctors;
ZHANG Zhen
- From:
Journal of Traditional Chinese Medicine
2026;67(15):1599-1603
- CountryChina
- Language:Chinese
-
Abstract:
This paper summarized professor ZHANG Zhen's clinical experience in treating rheumatoid arthritis （RA） complicated with anemia using self-formulated Yisui Shengxue Decoction （益髓生血汤） with modifications. It is proposed that the core pathogenesis of this condition is rooted in spleen and kidney depletion with insufficiency of essence and blood， while pathogenic dampness obstruction and internal blood stasis accumulation are the branches. The treatment principle focuses on tonifying the spleen and kidney， replenishing essence and nourishing the marrow， and enriching and generating blood， while simultaneously removing dampness and unblocking collaterals， activating blood and dissolving stasis. Based on this approach， Yisui Shengxue Decoction is used as the basic prescription， with flexible modifications according to syndrome patterns and clinical manifestations. For deficiency of both qi and blood combined with damp turbidity syndrome， medicinals that tonify qi and nourish blood， fortify the spleen and eliminate dampness， and mildly disperse obstruction are added. For wind-cold-dampness bi （痹） syndrome， medicinals that dispel wind and disperse cold， remove dampness and unblock the collaterals are incorporated. For wind-dampness-heat bi syndrome， medicinals that clear heat and eliminate dampness， unblock the collaterals and relieve bi are selected. For blood stasis obstructing the collaterals syndrome， medicinals that activate blood and resolve stasis， unblock the collaterals and relieve pain are combined. For yin deficiency with internal heat syndrome， medicinals that nourish yin and clear heat， cool blood and unblock the collaterals are prescribed.
