Mechanisms of Action of Angelica sinensis in Prevention and Treatment of Alzheimer's Disease： A Review
10.13422/j.cnki.syfjx.20252244
- VernacularTitle:当归防治阿尔茨海默病的作用机制研究进展
- Author:
Ting CHEN
1
;
Shuaiyin LI
1
;
Wanlin YANG
1
;
Xuemei WANG
2
;
Xixiang LI
2
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000，China
2. Gansu Provincial Hospital of Traditional Chinese Medicine， Lanzhou 730050，China
- Publication Type:Journal Article
- Keywords:
Angelica sinensis;
Alzheimer's disease;
compound formulas;
active ingredient;
molecular mechanisms
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(17):323-334
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease （AD） is a chronic neurodegenerative disorder with an unclear pathogenesis and currently no cure. It is characterized by a long disease course， diverse symptoms， and a persistent， difficult-to-treat nature， which greatly affects the quality of life of elderly patients. Traditional Chinese medicine （TCM） offers significant advantages in the treatment of AD， featuring multi-component， multi-target， and multi-pathway characteristics， with few adverse reactions and good safety. Angelica sinensis is a commonly used medicinal herb. As a frequently used clinical medicine for nourishing and activating blood， it shows significant efficacy in treating blood deficiency syndrome. In recent years， studies have revealed that A. sinensis exhibits significant activity in the prevention and treatment of AD. It contains various active components such as organic acids， volatile oils， and polysaccharides， and possesses pharmacological effects including anti-inflammatory， antioxidant， hepatoprotective， and neuroprotective properties. This article summarizes and outlines the mechanisms of A. sinensis and its compound formulas in the prevention and treatment of AD， providing a reference for its clinical application and the treatment of AD.
