Traditional Chinese Medicine Interventions in Oligoasthenospermia-related Signaling Pathways： A Review
10.13422/j.cnki.syfjx.20252291
- VernacularTitle:中医药干预少弱精子症相关信号通路的研究进展
- Author:
Tao ZHANG
1
;
Maobin YU
1
;
Zhiyu WU
1
;
Tang TANG
1
;
Yipeng ZHAO
1
;
Shikuan LU
1
;
Meijun LIU
2
;
Peihai ZHANG
2
Author Information
1. Clinical Medical College，Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610036，China
2. Hospital of Chengdu University of TCM，Chengdu 610072，China
- Publication Type:Journal Article
- Keywords:
oligoasthenospermia;
male infertility;
traditional Chinese medicine;
signaling pathway;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(17):314-322
- CountryChina
- Language:Chinese
-
Abstract:
Oligoasthenospermia （OAS） is the common cause of male infertility，bringing fertility problems to many families. Its pathogenesis is complex，involving endocrine disorders，reproductive system infection，oxidative stress injury，immune dysfunction and other aspects. At present，the Western medicine treatment of OAS is mainly based on drugs，surgery，and assisted reproductive technology. However，drug therapy has certain side effects，and long-term use is easy to produce drug resistance. Surgical treatment has certain trauma and risk. Assisted reproductive technology is not widely available because of its high cost. Therefore，there is an urgent need to develop safer，economical，and effective treatment options. Traditional Chinese medicine （TCM） has obvious advantages in the treatment of OAS. It can play a role in the treatment of OAS by reducing oxidative stress，inhibiting inflammatory response，reducing apoptosis，and regulating cell autophagy through multiple pathways and targets. Recent studies have shown that TCM compound prescriptions，single medicinal materials，medicinal pairs，and their active components can ameliorate OAS by regulating several key signaling pathways such as the phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt） pathway，Janus kinase 2/signal transducer and activator of transcription 3（JAK2/STAT3） pathway，nuclear factor E2-related factor 2/heme oxygenase-1 （Nrf2/HO-1） pathway，stem cell factor/tyrosine kinase receptor （SCF/c-kit） pathway，nuclear factor-κB （NF-κB） pathway，transforming growth factor-β （TGF-β）/Smads pathway，and extracellular regulated protein kinase （ERK） pathway. This article summarizes the role of the above signaling pathways in the occurrence and development of OAS and the therapeutic mechanism of TCM，aiming to provide a scientific basis for the clinical treatment of OAS and the research and development of drugs.
