Traditional Chinese Medicine Regulates NF-κB Signaling Pathway for Treating CP/CPPS： A Review
10.13422/j.cnki.syfjx.20252492
- VernacularTitle:中医药调控NF-κB信号通路治疗CP/CPPS的研究进展
- Author:
Pengdong YIN
1
;
Guangwei JIN
1
;
Shenglong LI
1
;
Ganggang LU
1
;
Yuanbo ZHAO
1
;
Yongqiang ZHAO
2
;
Xixiang LI
2
;
Jiuyun ZHOU
2
Author Information
1. School of Traditional Chinese and Western Medicine，Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730050，China
- Publication Type:Journal Article
- Keywords:
chronic prostatitis;
chronic pelvic pain syndrome;
nuclear factor （NF）-κB signaling pathway;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(17):301-313
- CountryChina
- Language:Chinese
-
Abstract:
Chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS） is a prevalent and complex condition in urology and one of the leading causes of chronic pelvic pain. Due to its prolonged duration and recurrent episodes，CP/CPPS significantly impacts patients' quality of life. Abnormal activation of the nuclear transcription factor-κB （NF-κB） pathway influences pathological processes such as the inflammatory response，oxidative stress，apoptosis，and tissue fibrosis in the body，thereby promoting the progression of CP/CPPS. Currently，Western medical therapies include antibiotics，pain relievers，α-blockers，and physiotherapy，yet they still fail to halt the pathological process of CP/CPPS. Research indicates that traditional Chinese medicine （TCM） can modulate the NF-κB pathway through a multi-target and multi-pathway approach，effectively reducing prostate tissue damage and prostate index and alleviating pain and lower urinary tract symptoms. On the basis of existing studies，this paper systematically examines the intrinsic connection between CP/CPPS and the NF-κB pathway and summarizes the effects of TCM active ingredients （e.g.，emodin，quercetin，and gentiopicroside），extracts （e.g.，Oldenlandia diffusa extract），classical medidcinal pairs （e.g.，Phellodendri Chinensis Cortex-Smilacis Glabrae Rhizoma），and compound prescriptions and Chinese patent medicines （e.g.，Qianliexiao decoction，Jiedu Huoxue decoction，Qianlie Shutong capsules） in treating CP/CPPS by regulating the NF-κB signaling pathway. The review of the research findings on treating CP/CPPS through this pathway aims to offer insights for clinical practice of TCM in the prevention and treatment of CP/CPPS，as well as to provide references for basic research and new drug development in this domain.
