Molecular Mechanisms of Traditional Chinese Medicine Interventions in Cancer Based on VEGF/VEGFR Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20260368
- VernacularTitle:基于VEGF/VEGFR信号通路探讨中医药干预癌症的分子机制
- Author:
Shicong WANG
1
;
Shuangling ZHOU
1
;
Suwen YOU
1
;
Bo SHI
1
;
Mingsan MIAO
1
Author Information
1. School of Pharmacy，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor （VEGF）/VEGF receptor （VEGFR） signaling pathway;
cancer;
traditional Chinese medicine （TCM） active component;
TCM extract;
TCM compound prescription
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(17):271-281
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors are major diseases with a high incidence worldwide and seriously threaten human health， and their occurrence and development are closely associated with the abnormal activation of multiple signaling pathways. Among them， the vascular endothelial growth factor （VEGF）/VEGF receptor （VEGFR） signaling pathway plays a key regulatory role in tumor angiogenesis， which can be widely implicated in tumor proliferation， invasion， and metastasis through regulating the expression of downstream signaling proteins and genes， serving as a key target for cancer targeted therapy. Traditional Chinese medicine （TCM） possesses unique advantages including multiple components， multiple targets， holistic regulation， and mild adverse reactions in cancer prevention and treatment. This paper systematically sorts out existing research findings and analyzes the anti-tumor mechanisms of TCM in modulating this signaling pathway. Furthermore， this paper summarizes that TCM active components （such as oxymatrine， quercetin， and celastrol）， extracts （such as Prunellae Spica extract and Cinnamomi Cortex extract）， and compound prescriptions （such as Yupingfeng San and modified Wenyang Sanjie Formula） can inhibit tumor angiogenesis， reverse epithelial-mesenchymal transition， improve the tumor microenvironment， promote cancer cell apoptosis， and suppress cancer cell proliferation， migration， and invasion by regulating the VEGF/VEGFR signaling pathway and its key molecules， thereby exerting anti-tumor effects. This review provides new ideas for the research and development of cancer drugs and the optimization of treatment regimens.
