Clinical Efficacy and Mechanism of Anmei Dan in Treating Insomnia with Amnesia Based on Principle of Treating Different Diseases with Same Method： A Review
10.13422/j.cnki.syfjx.20260305
- VernacularTitle:安寐丹异病同治失眠健忘临床疗效及作用机制的研究进展
- Author:
Qiqi FENG
1
;
Bo XU
1
;
Kang SUN
1
;
Miao ZHU
1
;
Zhi ZHANG
1
;
Jing XIA
1
;
Guangjing XIE
1
;
Yuan LIU
1
Author Information
1. Department of Inner Classics， Key Discipline of Traditional Chinese Medicine of National Administration of Traditional Chinese Medicine， Hubei University of Chinese Medicine，Hubei Shizhen Laboratory， Wuhan 430065， China
- Publication Type:Journal Article
- Keywords:
Anmei Dan;
treating different diseases with the same method;
insomnia;
amnesia;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(17):107-116
- CountryChina
- Language:Chinese
-
Abstract:
In modern society， the comorbidity of insomnia with amnesia has shown a significantly increasing incidence and become increasingly severe， emerging as a public health issue that endangers people's physical and mental health and quality of life. Anmei Dan （AMD）， originally recorded in the Shishi Milu by CHEN Shiduo in the Qing Dynasty， possesses profound theoretical foundations and distinct clinical advantages in ameliorating insomnia with amnesia. Basic research has unequivocally confirmed its definite therapeutic effects on insomnia with amnesia and revealed partial mechanisms. AMD is therefore a veritable classic prescription embodying the principle of treating different diseases with the same method for insomnia and amnesia. However， few researchers have reviewed the related research progress. This article systematically summarized the theoretical connotations of traditional Chinese medicine in treating insomnia with amnesia， delineated the multi-component material basis of AMD in ameliorating insomnia with amnesia （including various chemical components such as ginsenosides， jujubosides， and salvianolic acids）， and evaluate its multi-dimensional clinical efficacy （e.g.， prolonging total sleep time， improving sleep efficiency， and enhancing memory）. Moreover， it systematically summarizes the multi-pathway mechanisms of action. The results indicate that AMD has a clear material basis， definite clinical efficacy， and a favorable safety profile in ameliorating insomnia and amnesia. AMD may exert the therapeutic effect by regulating sleep-wake rhythms， enhancing synaptic plasticity， inhibiting neuroimmune inflammation， and modulating autophagy， oxidative stress， and energy metabolism. In conclusion， AMD exerts synergistic effects through multi-component， multi-dimensional， and multi-pathway approaches， serving as an important prescription for enriching and developing the theory of treating different diseases with the same method for insomnia with amnesia.
