Research advances in platelet-derived exosomes for tissue repair
10.13303/j.cjbt.issn.1004-549x.2026.07.025
- VernacularTitle:血小板来源外泌体在组织修复中的研究进展
- Author:
Tuerxunjiang NUERZHADAN
1
;
Yanchao XING
2
;
Lili CHEN
2
;
Haiying WANG
2
;
Jinjin ZHANG
1
Author Information
1. School of Postgraduates, Xinjiang Medical University, Urumqi 830054, China; Department of Blood Transfusion, General Hospital of Xinjiang Military Command, Urumqi 830099, China
2. Department of Blood Transfusion, General Hospital of Xinjiang Military Command, Urumqi 830099, China
- Publication Type:Journal Article
- Keywords:
platelet-derived;
exosomes;
tissue repair;
mechanism of action
- From:
Chinese Journal of Blood Transfusion
2026;39(7):985-991
- CountryChina
- Language:Chinese
-
Abstract:
Platelet-derived exosomes (PLT-Exos) are a subgroup of nanoscale extracellular vesicles released by platelets upon activatin. As key intercellular signaling mediators, they precisely regulate target cells through the delivery of functional molecules, exerting multiple biological effects that promote tissue repair. Accumulating evidence has demonstrated that PLT-Exos significantly facilitate the repair of various tissue injuries by modulating inflammatory responses, stimulating angiogenesis, activating key repair signaling pathways, and mediating stem cell homing. Furthermore, owing to their inherent targeting capacity and low immunogenicity, PLT-Exos have emerged as a promising platform for novel drug delivery carriers in tissue repair. This article systematically reviews the biological characteristics of PLT-Exos, their isolation and identification techniques, the underlying mechanisms of action, and recent advances in clinical application. It also addresses the current challenges in clinical translation, including standardized preparation, subpopulation heterogeneity, scalable production, and clinical implementation, aiming to provide a theoretical reference for both basic research and clinical translation of PLT-Exos in tissue repair.
