Establishment of multi-rule trend analysis for whole blood, washed red blood cells, and leukocyte-depleted suspended red blood cells
10.13303/j.cjbt.issn.1004-549x.2026.07.018
- VernacularTitle:全血、洗涤红细胞、去白细胞悬浮红细胞的多规则趋势分析
- Author:
Shanshan LIU
1
;
Ernan WAN
1
;
Xiaotang YU
1
;
Xue JIANG
1
;
Hong YUAN
1
Author Information
1. Jilin Province Blood Center, Changchun Blood Center, Changchun 130033, China
- Publication Type:Journal Article
- Keywords:
trend analysis;
quality control;
leukocyte-depleted suspended red blood cells
- From:
Chinese Journal of Blood Transfusion
2026;39(7):934-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To present the plotting of trend analysis charts and the application of multi-rule trend analysis method for monitoring the quality of whole blood, washed red blood cells, and leukocyte-depleted suspended red blood cells. Methods: Samples of whole blood, washed red blood cells, and leukocyte-depleted suspended red blood cells were collected in accordance with relevant protocols and requirements. The results of blood quality testing were compiled. The trend line charts were plotted for the deviation rates of volume, hemoglobin (Hb) content, supernatant protein content, and leukocyte residual count. In addition, the trend line chart were plotted for hematocrit and post-storage hemolysis rate. Results: The trend analysis rules for the deviation rate of volume from the standard were: 1
categorized as out-of-control, (3 of 4)
as warning, R
as warning, 8
as alert, and 12
as alert. For Hb content deviation rate, the rules were: <0% categorized as out-of-control; <20% but ≥0% (for whole blood) or <10% but ≥0% (for washed red blood cells and leukocyte-depleted suspended red blood cells) as a warning. For supernatant protein content deviation rate, the rules were: ≥0.0% as out-of-control, and >-10% but <0.0% as a warning. For hematocrit, the rules were: 1
as out-of-control and (3 of 4)
as warning. For leukocyte residual count deviation rate, the rules were: >0.0% as out-of-control, and >-10% but ≤0.0% as a warning. For post-storage hemolysis rate, the rule was: ≥0.8% out-of-control. Conclusion: The application of multi-rule trend analysis facilitates the timely identification of trend abnormalities and factors causing deviations in the collection and preparation processes of whole blood, washed red blood cells, and leukocyte-depleted suspended red blood cells, thereby providing reliable numerical evidence for their correction and adjustment.
