Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
10.1016/j.livres.2021.06.001
- Author:
Fang Wang
;
Peter Breslin S J
;
Wei Qiu
- Publication Type:Review
- From:
Liver Research
2021;5(4):195-203
- CountryChina
- Language:English
-
Abstract:
Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activation of oncogenes stimulates cell growth and survival, while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth. In this review, we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years. These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients.
