Clinical Characteristics and Outcomes of Paediatric Hyperthyroidism: A 10-Year Single Centre Retrospective Cohort Study from Negeri Sembilan
https://doi.org/10.15605/jafes.041.S1
- Author:
Munzir Jamil
1
;
Mastura Ibrahim
1
;
Meenal Mavinkurve
2
Author Information
1. Department of Paediatrics, Hospital Tuanku Ja'afar
2. Department of Paediatrics, International Medical University
- Publication Type:Journal Article
- MeSH:
Child;
Retrospective Studies;
Hyperthyroidism
- From:
Journal of the ASEAN Federation of Endocrine Societies
2026;41(S1):137-138
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:The commonest cause of paediatric hyperthyroidism is
Graves' disease. Previous studies in the Malaysian context
haven’t captured data from Negeri Sembilan. This study
aims to describe the demographic and clinical features
of children with hyperthyroidism from Hospital Tuanku
Jaafar.
Methodology:A retrospective cohort study collating socio-demographic
and clinical data from electronic medical records was
conducted. Statistical analysis was conducted using
Microsoft Excel (v2602).
Results:Fourteen children between 2015 and 2025 were identified.
Females comprised 93% (n = 13). The mean age at diagnosis
was 9.76 ± 3.4 years, with 64% (n = 9) aged >10 years.
Malay ethnicity comprised 64% (n = 9). Family history was
positive in 43% (n = 6). Three (21%) children were detected on routine screening. At presentation, 50% (n = 7) were
prepubertal and 36% (n = 5) were underweight, with mean
BMI SDS −1.4 ± 1.2. All had high fT4 78.43 ± 72 pmol/L and
suppressed TSH TRAb positivity was 86% (n = 12). AntiTPO or anti-thyroglobulin antibodies positivity was 79%
(n = 11). In one child, all three antibodies were negative.
Thyroiditis was the commonest ultrasound finding.
Carbimazole starting dose was 0.6 mg/kg/day and average
treatment duration was 3.5 ± 2.4 years, which achieved
biochemical euthyroidism in 49 days. Relapse rate on
carbimazole was 57% (n = 8). No adverse effects occurred,
and none had definitive therapy. Currently, 71% (n = 10)
are euthyroid on a mean carbimazole dose of 0.2 mg/kg/
day; one is off carbimazole. Current height is −1.1 ± 1.31
SD and BMI SDS −0.42 ± 1.7 SD respectively.
Conclusion:Graves’ disease is the commonest form of paediatric
hyperthyroidism in Negeri Sembilan, affecting prepubertal
Malay females who commonly present with thyrotoxicosis.
Carbimazole effectively achieves biochemical euthyroidism
with minimal side effects. However, linear growth is
affected. Future studies should evaluate the factors
associated with these findings.
- Full text:2026081009011323125EP_P006.pdf
