Central Precocious Puberty: Evaluation of Predicted and Final Adult Height in Girls Who Received GnRH Analogs
https://doi.org/10.15605/jafes.041.S1
- Author:
Adam Mohd Noor
1
;
Muhammad Yazid Jalaludin
2
;
Lixian Oh
2
Author Information
1. Hospital Raja Permaisuri Bainun Ipoh
2. Universiti Malaya Medical Centre
- Publication Type:Journal Article
- MeSH:
Adult;
Female;
Puberty, Precocious;
Gonadotropin-Releasing Hormone;
World Health Organization
- From:
Journal of the ASEAN Federation of Endocrine Societies
2026;41(S1):124-
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:Central precocious puberty (CPP) is defined as the early occurrence of puberty before the age of 8 years in girls and 9 years
in boys. CPP has many implications for the patient’s physical, emotional, and psychological aspects. The most soughtafter benefit of the treatment is the preservation of the growth potential of final adult height. This study aims to evaluate
the predicted and final adult height in girls with CPP who received treatment in the University Malaya Medical Centre
(UMMC), Malaysia.
Methodology:In this retrospective longitudinal study, 32 CPP patients who received treatment with GnRH analogs in UMMC between
2010 and 2025 were identified. The demographic and clinical data of the patients were retrieved from the medical record
system and analyzed.
Results:The study revealed that predicted adult height (PAH) by using bone age closely approximated the actual final adult height
(FAH) with no significant difference observed (p = 0.793), and a strong positive correlation (r = 0.75, p <0.001). The predicted
height based on the genetic potential of mid-parental target height (MPTH) showed a significant underestimation of FAH
(mean difference = -1.89 cm, p <0.01), although it remained a robust predictor (r = 0.75, p <0.01). Across age groups, the
correlation between PAH and FAH was strongest in girls aged 6–8 years old. Notably, girls treated before age 6 exhibited
a significant height gain compared to initial prediction values, underscoring the importance of early intervention.
Conclusion:From this study, we concluded that the FAH outcome in girls with CPP who received treatment with GnRH analogs is
preserved, similar to the PAH calculated by bone age. However, the FAH is significantly lower than the MPTH (genetic
potential). The baseline height SDS appears to be a strong predictor of FAH. The bone age value is the strongest predictor
of FAH. The preservation of adult height potential is more prominent when subjects developed CPP before 6 years and
were treated immediately.
- Full text:202608051012412472OP_P002.pdf
