Baseline Physical Activity Enhances GLP-1 Receptor Agonist Weight Loss in Obese Malaysian Patients with T2DM
https://doi.org/10.15605/jafes.041.S1
- Author:
Noor Hafizah Ab Hamid
1
;
Mohammad Zulkarnain Bidin
2
;
Ooi Chuan Ng
3
Author Information
1. Department of Internal Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2. Department of Internal Medicine, Hospital Sultan Abdul Aziz Shah, Universiti Putra Malaysia
3. Department of Internal Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia;Department of Internal Medicine, Hospital Sultan Abdul Aziz Shah, Universiti Putra Malaysia
- Publication Type:Journal Article
- MeSH:
Humans;
Glucagon-Like Peptide-1 Receptor Agonists;
Exercise;
Weight Loss;
Obesity;
Diabetes Mellitus, Type 2
- From:
Journal of the ASEAN Federation of Endocrine Societies
2026;41(S1):61-62
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:While Glucagon-like peptide-1 receptor agonists (GLP-1
RAs) are effective for weight reduction in type 2 diabetes
mellitus (T2DM), interindividual variability exists.
Lifestyle factors, particularly baseline physical activity,
may modify weight loss outcomes. This study examined
whether baseline activity influences GLP-1 RA efficacy in
Malaysian patients.
Methodology:A retrospective cohort of adults with obesity and T2DM
receiving GLP-1 RAs (semaglutide or liraglutide) from
January 2023 to December 2024 was analyzed. Baseline
physical activity was classified as active or inactive.
Primary outcomes were achievement of ≥3 and ≥5% weight
loss over 6–12 months. Associations were assessed using
Fisher’s exact test and logistic regression.
Results:Among GLP-1-treated patients, those reporting baseline
physical activity were more likely to achieve ≥3% weight loss
and demonstrated trends toward higher, ≥5%, weight loss.
Logistic regression suggested baseline activity increased
the odds of clinically meaningful weight reduction, though
statistical significance was limited by sample size.
Conclusion:Baseline physical activity may enhance GLP-1 receptor
agonist-mediated weight loss in obese patients with T2DM.
Integrating lifestyle interventions with pharmacotherapy
may optimize treatment outcomes. Larger prospective
studies are warranted to confirm these findings.
- Full text:2026080316161189339EP_A077.pdf
