A Single-Centre Malaysian Cohort Study on Predictors of Glycemic Improvement 12 Months After Bariatric Surgery
https://doi.org/10.15605/jafes.041.S1
- Author:
Anis Amalina Mohd Nadzri
1
;
Mohd Shazli Draman
1
;
Haron Ahmad
2
Author Information
1. KPJ Healthcare University
2. KPJ Damansara Specialist Hospital
- Publication Type:Journal Article
- MeSH:
Cohort Studies;
Bariatric Surgery
- From:
Journal of the ASEAN Federation of Endocrine Societies
2026;41(S1):59-
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:Bariatric surgery is an established intervention for obesity
and its metabolic complications, including diabetes
mellitus. However, most studies are from Western
populations with limited data in Malaysia. This study
evaluated glycemic status improvements and identified
predictors of hemoglobin A1c (HbA1c) reduction at 12
months following bariatric surgery to contribute regional
data to Southeast Asia.
Methodology:This retrospective analysis included 110 patients who
underwent bariatric surgery between 2015 and 2025.
Pre- and post-operative parameters, including HbA1c,
body mass index (BMI), and lipid profiles, were collected
at 1, 3, 6, 9, and 12 months and evaluated as potential
predictors of glycemic status improvement at 12 months.
Univariate analysis followed by stepwise multivariate
linear regression was performed to identify predictors of
HbA1c improvement at 12 months. Regression coefficients
(B), 95% confidence intervals, and p-values were reported.
Results:The mean age was 40.5 years with a mean baseline BMI of
43.49 kg/m²; 58% were female. At baseline, 60.9% (n = 67)
had diabetes, 30.9% (n = 34) prediabetes, and 8.2% (n = 9)
normal HbA1c. In univariate analysis, baseline HbA1c (B
= 0.579, p <0.001), age (B = −0.051, p = 0.034), and sex (B =
1.123, p = 0.044) were significantly associated with HbA1c
change. In multivariate analysis, the final model identified
baseline HbA1c, BMI difference at 12 months, and TG
difference at 12 months as independent predictors of HbA1c change. Baseline HbA1c was the strongest predictor (B =
0.857, p <0.001) indicating that higher baseline HbA1c was
associated with greater change over time. BMI difference
at 12 months was also significantly associated with HbA1c
change (B = 0.046, p = 0.016), indicating that greater weight
loss contributed to improved glycemic control. Similarly,
TG difference at 12 months was a significant predictor (B =
0.337, p = 0.023). The model explained 86.8% of the variation
in HbA1c change (adjusted R² = 0.868).
Conclusion:Bariatric surgery resulted in significant weight loss and
improvement in glycemic status at 12 months, with baseline HbA1c, BMI differences, and TG reductions emerging
as key predictors of glycemic improvement in a Malaysian
cohort.
- Full text:202608031556417439EP_A073.pdf
