Experimental study of epigallocatechin gallate-loaded hydrogel scaffold for the treatment of periodontitis
10.19405/j.cnki.issn1000–1492.2026.06.006
- VernacularTitle:负载表没食子儿茶素没食子酸酯的水凝胶支架用于牙周炎治疗的实验研究
- Author:
Longge LIU
1
;
Jing MAO
1
;
Huimin ZHENG
1
;
Wei LI
1
Author Information
1. College & Hospital of Stomatology， Anhui Medical University， Key Laboratory of Oral Disease Research of Anhui Province， Hefei 230032
- Publication Type:Journal Article
- Keywords:
hyaluronic acid;
epigallocatechin gallate;
hydrogel scaffold;
periodontitis;
anti-inflammatory;
antioxidant
- From:
Acta Universitatis Medicinalis Anhui
2026;61(6):1013-1020
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the structural characteristics， biocompatibility， anti-inflammatory and antioxidant properties of hyaluronic acid （HA）/silk fibroin （SF） composite hydrogel scaffolds loaded with epigallocatechin gallate （EGCG）， and to provide a new material basis for the treatment of periodontitis. MethodsThe composite hydrogel scaffolds were constructed by cross-linking HA and SF and loaded with EGCG. The water absorption rate， degradation property and material characteristics were detected by scanning electron microscopy. The cytocompatibility and anti-inflammatory and antioxidant properties were evaluated by in vitro experiments. ResultsThe EGCG-loaded scaffolds exhibited a porous network structure and desirable swelling properties. In vitro experiments demonstrated that the scaffolds possessed good biocompatibility， along with the ability to inhibit the expression of inflammatory factors and scavenge reactive oxygen species. ConclusionThe HA/SF-EGCG composite scaffolds have excellent biocompatibility and dual functional activities of anti-inflammatory and antioxidant， providing a new strategy for improving the clinical treatment effect of periodontitis.
