Research Progress on Application of Cerebrospinal Fluid Liquid Biopsy in Brain Metastasis from Lung Cancer
10.3971/j.issn.1000-8578.2026.25.0977
- VernacularTitle:脑脊液液体活检在肺癌脑转移中的应用研究进展
- Author:
Yidie WANG
1
;
Jie HUANG
2
;
Xueqin CHEN
3
Author Information
1. The Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China.
2. Department of Thoracic Oncology, Hangzhou Cancer Hospital, Hangzhou 310002, China.
3. The Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China;Department of Thoracic Oncology, Hangzhou Cancer Hospital, Hangzhou 310002, China;Department of Thoracic Oncology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China.
- Publication Type:REVIEWS
- Keywords:
Lung cancer;
Brain metastasis;
Meningeal metastasis;
Liquid biopsy;
Cerebrospinal fluid
- From:
Cancer Research on Prevention and Treatment
2026;53(7):572-576
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the most common malignant tumors. Brain metastasis, especially meningeal metastasis, is a fatal complication of lung cancer. The sensitivity of traditional diagnostic methods for this disease is limited. As a new technology, cerebrospinal fluid liquid biopsy can noninvasively and dynamically detect the molecular characteristics of intracranial tumors. Cerebrospinal fluid directly contacts the central nervous system lesions. It contains more unique and representative tumor-derived molecular information compared with those obtained from other body fluids such as blood for lung cancer meningeal metastasis, thus remarkably improving the diagnosis and personalized treatment of lung cancer meningeal metastasis. This work reviews the research progress on cerebrospinal fluid liquid biopsy in lung cancer brain metastasis and explores its value in guiding targeted therapy, delineating drug resistance, and evaluating prognostic progression to provide new directions for the clinical diagnosis and treatment of lung cancer brain metastasis.
