Latent tuberculosis infection status and influencing factors among close contacts of patients with bacteriologically confirmed pulmonary tuberculosis
10.19428/j.cnki.sjpm.2026.250323
- VernacularTitle:病原学阳性肺结核患者密切接触者结核潜伏感染状况及影响因素分析
- Author:
Huaiqing ZHANG
1
;
Kaikan GU
1
;
Chenlei YU
2
;
Jing YAO
1
;
Zhihong LI
1
;
Zhiying HAN
1
;
Jing LI
2
Author Information
1. Shanghai Jing’an District Center for Disease Control and Prevention (Shanghai Jing’an District Health Supervision Institute), Shanghai 200072, China
2. Division of Tuberculosis and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention (Shanghai Institute of Preventive Medicine), Shanghai 201107, China
- Publication Type:Journal Article
- Keywords:
pulmonary tuberculosis;
Mycobacterium tuberculosis;
latent tuberculosis infection;
close contact;
influencing factor
- From:
Shanghai Journal of Preventive Medicine
2026;38(6):427-431
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the status and influencing factors of latent tuberculosis infection (LTBI) among close contacts of patients with bacteriologically confirmed pulmonary tuberculosis in Jing’an District, Shanghai, and to provide scientific evidence for the development of tuberculosis infection testing and preventive intervention strategies for close contacts of bacteriologically positive patients. MethodsFrom October 2022 to October 2023, patients with bacteriological confirmed pulmonary tuberculosis registered in Jing’an District, Shanghai, and their close contacts were enrolled as the research subjects. The close contacts were screened for tuberculosis infection using the interferon-γ release assay (IGRA). The chi-square test and binary logistic regression model were used to analyze factors influencing LTBI. ResultsA total of 112 close contacts were included, of whom 30 (26.79%) were male and 82 (73.21%) were female. The age ranged from 1 to 86 years, with a median (25th, 75th percentiles) of 47.50 (32.25, 61.00) years. The infection rate of LTBI was 21.43% (24/112), and the incidence of active pulmonary tuberculosis was 2.68% (3/112). Univariate analyses showed that a positive sputum smear of the index case, being a direct relative of the index case, co-living, and not wearing a mask were significantly associated with LTBI (all P<0.05). Multivariate logistic regression analyses showed that the risk of latent infection in close contacts of the index case with a positive sputum smear was 6.50 times higher than in those with a negative sputum smear (95%CI: 1.82‒23.25, P=0.004). ConclusionThe infection rate of LTBI in close contacts of patients with bacteriologically confirmed pulmonary tuberculosis in Jing’an District, Shanghai, is relatively high, and close contacts of sputum smear-positive patients face an even higher risk of infection. Therefore, tuberculosis infection screening and follow-up management should be strengthened for this population.
