Effect of action observation therapy based on mirror neuron system combined with low-frequency repetitive transcranial magnetic stimulation on post-stroke unilateral spatial neglect
10.3969/j.issn.1006-9771.2026.07.004
- VernacularTitle:基于镜像神经元理论的动作观察疗法联合低频重复经颅磁刺激对脑卒中后单侧空间忽略的效果
- Author:
Fei ZHANG
1
;
Boxun FU
1
;
Hui SHEN
1
;
Jin CHEN
2
Author Information
1. Department of Rehabilitation Medicine, Suqian Integrated Traditional Chinese and Western Medicine Hospital, Suqian, Jiangsu 223800, China
2. Rehabilitation Medicine College of Jiangsu Medical Vocational College, Yancheng, Jiangsu 224000, China
- Publication Type:Journal Article
- Keywords:
stroke;
action observation therapy;
low-frequency repetitive transcranial magnetic stimulation;
unilateral spatial neglect
- From:
Chinese Journal of Rehabilitation Theory and Practice
2026;32(7):768-775
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the effect of action observation therapy (AOT) combined with low-frequency repetitive transcranial magnetic stimulation (rTMS) on post-stroke unilateral spatial neglect. MethodsA total of 108 patients with post-stroke unilateral spatial neglect admitted to Suqian Integrated Traditional Chinese and Western Medicine Hospital from January, 2023 to March, 2024 were enrolled. The patients were randomly allocated to AOT group, rTMS group and combined group with 36 patients in each group. All the groups received conventional treatment. The AOT group additionally received AOT, the rTMS group additionally received rTMS, and the combined group received both AOT and rTMS, for four weeks. Before and after treatment, the patients were assessed using the Montreal Cognitive Assessment (MoCA), Fugl-Meyer Assessment (FMA), modified Barthel Index (MBI), Chinese Behavioural Inattention Test-conventional test (CBIT-C) and CBIT-behavioural test (CBIT-B). The latency and amplitude of the N20 potential on the affected side were also measured. ResultsThree patients dropped out from each group. After intervention, significant main effects of time (F > 77.096, P < 0.001) and group (F > 5.119, P < 0.01) and significant time-by-group interaction effects (F > 3.320, P < 0.05)were observed in the MoCA, FMA, MBI, and CBIT-C scores. For the CBIT-B score, the main effects of time (F = 367.430, P < 0.001) and group (F = 4.995, P = 0.008) were significant. After intervention, MoCA, FMA, MBI, CBIT-C and CBIT-B scores, and N20 amplitude and latency were better in the combined group than in the AOT and rTMS groups (P < 0.05). ConclusionThe combination of AOT and rTMS may further ameliorate cognitive function, motor function, activities of daily living, and the degree of spatial neglect in post-stroke patients with unilateral spatial neglect, potentially attributable to improved nerve conduction function.
