Effect of repetitive transcranial magnetic stimulation on prolonged disorders of consciousness after stroke
10.3969/j.issn.1006-9771.2026.07.002
- VernacularTitle:重复经颅磁刺激对脑卒中后慢性意识障碍的效果
- Author:
Yaohui HUANG
1
;
Xiangming YE
2
;
Yong LIU
2
;
Pei TANG
3
;
Yishu LU
2
Author Information
1. Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
2. Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China
3. Department of Neuroelectrophysiology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China
- Publication Type:Journal Article
- Keywords:
stroke;
prolonged disorders of consciousness;
repetitive transcranial magnetic stimulation;
hyperbaric oxygen therapy
- From:
Chinese Journal of Rehabilitation Theory and Practice
2026;32(7):752-759
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on prolonged disorders of consciousness (pDoC) after stroke. MethodsSixty patients with pDoC admitted to Zhejiang Provincial People's Hospital from January to July, 2024 were randomly assigned into control group (n = 30) and observation group (n = 30). Both groups received conventional rehabilitation therapy combined with hyperbaric oxygen therapy, while the observation group received rTMS in addition, for four weeks. Before and after treatment, they were assessed with Coma Recovery Scale-Revised (CRS-R), National Institutes of Health Stroke Scale (NIHSS), and bilateral N20 amplitude and latency of somatosensory-evoked potential (SEP), while consciousness status classification and Judson classification were recorded. ResultsOne case in the control group and two in the observation group dropped out. Significant time main effects and interaction effects were observed in CRS-R score (F = 118.420, P < 0.001; F = 23.980, P < 0.001, respectively) and NIHSS score (F = 103.376, P < 0.001; F = 14.241, P < 0.001, respectively). Significant group main effects, time main effects and interaction effects were observed in N20 amplitude (F > 4.303, P < 0.05) and N20 latency (F > 7.569, P < 0.05). Simple effects analysis showed CRS-R score, N20 amplitude, NIHSS score and N20 latency were better in the observation group than in the control group (P < 0.05) after the intervention, while the consciousness status classification and Judson classification were also better (|Z| > 2.160, P < 0.05). ConclusionrTMS can further promote recovery of consciousness, improve neurological function, and enhance the integrity of central conduction pathways in patients with pDoC after stroke.
