The combined use of serum E-FABP and ENA-78 levels with CTA for evaluating the degree of coronary atherosclerotic stenosis in patients with coronary heart disease
10.13491/j.issn.1004-714X.2026.03.014
- VernacularTitle:血清 E-FABP、ENA-78 水平联合 CTA 评估冠心病患者冠状动脉粥样硬化狭窄程度
- Author:
Li QI
1
;
Bao WU
1
;
Wenrui LI
1
;
Xiuyong HE
1
;
Wei LI
2
Author Information
1. Image Center, Ankang Hospital of Traditional Chinese Medicine, Ankang 725000, China.
2. Cardiovascular Medicine Department, Ankang Hospital of Traditional Chinese Medicine, Ankang 725000, China.
- Publication Type:OriginalArticles
- Keywords:
Computed tomography angiography;
Epithelial fatty acid-binding protein;
Epithelial neutrophil-activating peptide-78;
Coronary heart disease;
Severity of coronary atherosclerotic stenosis
- From:
Chinese Journal of Radiological Health
2026;35(3):401-406
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the performance of serum epithelial fatty acid-binding protein (E-FABP) and epithelial neutrophil-activating peptide-78 (ENA-78) levels combined with computed tomography angiography (CTA) in assessing the severity of coronary atherosclerotic (CA) stenosis in patients with coronary heart disease (CHD). Methods A total of 160 CHD patients admitted to our hospital between October 2021 and October 2023 were enrolled. Based on coronary angiography results, patients were divided into a mild stenosis group (65 cases) and a moderate-to-severe stenosis group (95 cases). All patients underwent CTA. Serum levels of E-FABP and ENA-78 were measured using ELISA. Receiver operating characteristic curves were plotted to determine the diagnostic cutoff value of CTA combined with serum E-FABP and ENA-78 for assessing CA stenosis severity. A fourfold table was used to evaluate the diagnostic performance of CTA combined with serum E-FABP and ENA-78. Results CTA identified 64 patients with stenosis <50% and 96 patients with stenosis ≥50%. The agreement rates between CTA and coronary angiography were 87.69% in the mild group and 92.63% in the moderate-to-severe group. Serum levels of E-FABP and ENA-78 were significantly higher in the moderate-to-severe group than in the mild group (P<0.05). According to receiver operating characteristic analysis, the areas under the curve for E-FABP, ENA-78, and CTA in diagnosing CA stenosis severity were 0.828, 0.855, and 0.901, respectively. The areas under the curve for their combined use was 0.986. The diagnostic accuracies of CTA, E-FABP, and ENA-78 were 90.63%, 83.75%, and 83.23%, respectively, while the combined approach achieved a diagnostic accuracy of 93.13%. Conclusion Serum levels of E-FABP and ENA-78 are significantly elevated in CHD patients with moderate-to-severe CA stenosis. The combination of CTA with E-FABP and ENA-78 can improve the accuracy of assessing the severity of CA stenosis.
