Clinical diagnostic value of MRI combined with serum CYR61 and CXCL1 for acute stroke
10.13491/j.issn.1004-714X.2026.03.013
- VernacularTitle:MRI联合血清CYR61、CXCL1对急性脑卒中的诊断价值
- Author:
Juan TIAN
1
;
Huifang WANG
1
;
Weijing ZHANG
2
Author Information
1. Department of Imaging, The First Hospital of Yulin, Yulin 719000, China.
2. Department of Neurology, The First Hospital of Yulin, Yulin 719000, China.
- Publication Type:OriginalArticles
- Keywords:
Acute stroke;
Magnetic resonance imaging;
Cysteine rich 61;
C-X-C motif chemokine ligand 1;
Diagnosis
- From:
Chinese Journal of Radiological Health
2026;35(3):394-400
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical utility of combining magnetic resonance imaging (MRI) findings with serum levels of cysteine-rich protein 61 (CYR61) and C-X-C motif chemokine ligand 1 (CXCL1) for early identification of acute stroke. Methods The study was conducted 205 patients with suspected acute stroke admitted to the neurology department of our hospital between April 2021 and April 2024. Based on brain CT imaging and clinical diagnosis, 119 patients were acute stroke group and 86 to non-acute stroke group. All patients underwent MRI examination. Serum levels of CYR61 and CXCL1 were measured. Receiver operating characteristic (ROC) curves were generated to assess diagnostic value, and Kappa tests were used to performed to evaluate the consistency. Results Serum level of CYR61 and CXCL1were significantly higher in the acute stroke group than in the non-acute stroke group (P<0.05). The area under the ROC curve (AUC) for serum CYR61 in diagnosing acute stroke was 0.867 (95%CI: 0.819-0.915), with diagnostic threshold of 6.02 μg/L; for CXCL1, the AUC was 0.818 (95%CI: 0.762-0.875), with a threshold of 1.28 ng/mL. The Kappa values for agreement between MRI, serum CYR61, and CXCL1 clinical diagnosis results were 0.766, 0.586, and 0.528, respectively, the Kappa value for the consistency between the combination of the three with clinical diagnosis results was 0.920 (P<0.05). The sensitivity, negative predictive value, and accuracy of the combination of MRI, serum CYR61, and CXCL1 were obviously higher than that of the individual diagnosis, and the specificity and positive predictive value were obviously higher than that of the individual diagnosis of serum CYR61 and CXCL1 (P<0.05). Conclusion The clinical diagnostic accuracy of MRI combined with serum CYR61 and CXCL1 in the diagnosis of acute stroke is high, the combined diagnosis is obviously better than the individual diagnosis of each indicator.
