Research progress on the mechanisms of pharmacological effects and detoxification of Tripterygium wilfordii and its active ingredients in nephrotic syndrome
- VernacularTitle:雷公藤及其活性成分在肾病综合征中的药理作用及减毒机制研究进展
- Author:
Zhifen ZHAO
1
;
Xiangge REN
1
;
Jiawei ZHANG
1
;
Jianye REN
1
;
Wensheng ZHAI
2
Author Information
1. Pediatric Hospital，The First Affiliated Hospital of Henan University of CM，Zhengzhou 450099，China;School of Pediatrics，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Pediatric Hospital，The First Affiliated Hospital of Henan University of CM，Zhengzhou 450099，China
- Publication Type:Journal Article
- Keywords:
Tripterygium wilfordii;
active ingredients;
nephrotic syndrome;
pharmacological mechanism;
detoxification mechanism
- From:
China Pharmacy
2026;37(14):1931-1936
- CountryChina
- Language:Chinese
-
Abstract:
Nephrotic syndrome （NS） is a glomerular disease characterized by massive proteinuria， hypoalbuminemia， edema， and hyperlipidemia. Tripterygium wilfordii exhibits remarkable efficacy in the prevention and treatment of renal diseases； however， its hepatotoxicity， nephrotoxicity， and other factors limit its clinical application. This article systematically reviews the mechanisms of pharmacological effects and detoxification of T. wilfordii and its active ingredients in the treatment of NS. The results show that the main active components of T. wilfordii include tripterygium glycosides， triptolide， and triptriolide， etc. T. wilfordii and its active ingredients exert significant renal protective effects by protecting glomerular podocytes， repairing the glomerular filtration barrier， regulating abnormal immune and inflammatory responses， inhibiting oxidative stress injury， and blocking renal fibrosis， thereby effectively reducing proteinuria， improving renal function， and lowering the recurrence rate of NS. Traditional Chinese medicine compatibility （e.g. T. wilfordii combined with Lysimachia christinae ， Cuscuta chinensis ethanol extract， and Paeonia lactiflora ， respectively） can regulate anti-inflammatory and antioxidant levels and optimize drug metabolic pathways. Combined with modern preparation technologies （e.g.， triptolide self-microemulsion drug delivery system）， these strategies can effectively antagonize the hepatotoxicity， nephrotoxicity， and other factors of T. wilfordii .
