Compatibility of commonly used intravenous drugs in ICU patients with severe pneumonia
- VernacularTitle:ICU重症肺炎患者常用静脉药物的配伍相容性探讨
- Author:
Lei ZHANG
1
;
Xiao LI
2
;
Jing WANG
2
;
Xiaokai REN
1
;
Zhanjun DONG
3
Author Information
1. College of Pharmacy，Hebei Medical University，Shijiazhuang 050017，China
2. Dept. of Pharmacy，Hebei General Hospital，Shijiazhuang 050051，China
3. College of Pharmacy，Hebei Medical University，Shijiazhuang 050017，China;Dept. of Pharmacy，Hebei General Hospital，Shijiazhuang 050051，China
- Publication Type:Journal Article
- Keywords:
intravenous drugs;
compatibility;
safety;
ICU;
severe pneumonia
- From:
China Pharmacy
2026;37(14):1886-1891
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To quantitatively assess the compatibility risk of commonly used intravenous drugs in intensive care unit （ICU） patients with severe pneumonia， and provide a reference for reducing the incidence of adverse events caused by incompatibility. METHODS The PASS clinical pharmacy management system was used to retrospectively collect the data of patients diagnosed with “severe pneumonia” in the ICU of Hebei General Hospital from January 2023 to June 2025， and the commonly used intravenous drugs and medication frequency were extracted. Based on authoritative databases such as Micromedex and Stabilis as well as relevant literature， the compatibility data of commonly used intravenous drugs with 0.9% Sodium chloride injection and 5% Glucose injection were summarized. The theoretical and actual compatibility risk values were calculated using formulas， and high-risk drugs were screened and the compatibility query table was drawn. RESULTS A total of 158 ICU patients with severe pneumonia were treated with 89 intravenous drugs， and 24 drugs with high compatibility risk were identified. The drug with the highest theoretical compatibility risk value was Amphotericin B for injection （risk value 146）， and the drug with the highest actual compatibility risk value was Propofol medium and long chain fat emulsion injection （risk value 8 740）. Among the 24 high-risk drugs， six drugs， namely Esomeprazole sodium for injection， Ambroxol hydrochloride injection， Midazolam injection， Methylprednisolone sodium succinate for injection， Furosemide injection， and Cefoperazone sodium and sulbactam sodium for injection， simultaneously ranked among the top 15 in both theoretical and actual compatibility risk rankings. Among 650 pairwise compatibility combinations of the 24 drugs， 24.62% were compatible， 11.23% were incompatible， 6.77% had conflicting evidence， and 57.38% had missing evidence. CONCLUSIONS This study quantitatively analyzed the medication safety of commonly used intravenous drugs in ICU patients with severe pneumonia， identified 24 drugs with high compatibility risk， and established a compatibility query table for high-risk drugs， which helps reduce the risk of ICU compatibility adverse events.
