Research advances of biohybrid robotics in medical applications
10.12206/j.issn.2097-2024.202601003
- VernacularTitle:生物混合机器人在医药领域的研究进展
- Author:
Wenwei WU
1
;
Miao LIN
2
;
Jun ZHUANG
1
Author Information
1. Shanghai Institute for Science of Science, Shanghai 200031, China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Reviews
- Keywords:
biohybrid robots;
precision medicine;
drug delivery;
drug evaluation;
bio–mechanical interface
- From:
Journal of Pharmaceutical Practice and Service
2026;44(7):335-340
- CountryChina
- Language:Chinese
-
Abstract:
Biohybrid robots are hybrid systems that deeply integrate living biological components （such as cells, tissues, organs, or microorganisms） with artificial synthetic components （including sensors, actuators, control systems, and structural materials）. Focusing on key advancements in cellular/microbial-level and tissue-level biohybrid robots, the applications in two major scenarios: targeted drug delivery in vivo and drug evaluation in vitro were reviewed. International research progress demonstrated that biohybrid robots offered novel solutions for overcoming deep tissue delivery barriers, enhancing biocompatibility, and enabling real-time monitoring. However, their clinical translation still faced critical challenges, including reproducibility, in vivo/in vitro nutrient supply, encapsulation technologies, and safety regulatory frameworks.
