Application of mass spectrometry imaging in the diagnosis and molecular mechanism of liver cancer
10.12206/j.issn.2097-2024.202411006
- VernacularTitle:质谱成像技术在肝癌诊断与分子机制研究中的应用
- Author:
Qianxue YU
1
;
Yongsheng HU
2
;
Yanqiu HUANG
3
;
Xiaofei CHEN
4
;
Gao LI
1
;
Yue LIU
4
Author Information
1. School of Pharmacy, Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji 133002, China.
2. No. 906 Hospital, Joint Logistic Support Force, Wenzhou 325000, China.
3. School of Pharmacy, Guangxi Medical University, Nanning 530021, China.
4. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Reviews
- Keywords:
mass spectrometry imaging;
liver cancer;
early diagnosis;
precision medicine
- From:
Journal of Pharmaceutical Practice and Service
2026;44(7):329-334
- CountryChina
- Language:Chinese
-
Abstract:
Mass spectrometry imaging （MSI） is an emerging molecular imaging technique that combines high spatial resolution and the ability to acquire molecular information. This technology can directly obtain spatial distribution maps of metabolites, proteins, lipids and other molecules in tumor tissues, reveal the abnormal molecular changes during the occurrence and development of liver cancer, and make up for the deficiency of information at the molecular level in traditional imaging （such as CT, MRI）. In liver cancer research, MSI has demonstrated unique advantages and application potential in early diagnosis and screening, precise classification, tumor heterogeneity analysis, and exploration of molecular mechanisms. The principle characteristics of MSI technology and its latest progress in the early diagnosis, classification and molecular mechanism research of liver cancer were reviewed, and the current challenges and future development directions were discussed, which aimed to provide a new perspective and theoretical basis for an in-depth understanding of the pathological mechanism of liver cancer and promoted its precise diagnosis and treatment.
