Research progress on the pathogenesis of gastric ulcer and gastric cancer caused by Helicobacter pylori
10.3969/j.issn.1006-2483.2026.04.031
- VernacularTitle:幽门螺杆菌致胃溃疡胃癌的发病机制研究进展
- Author:
Haihua ZHOU
1
;
Wei ZHANG
2
;
Shuai YUAN
1
;
Shengli SHI
2
;
Jianping XU
3
Author Information
1. Department of Endoscopy Center, Xiaolan Clinical Institute of Shantou University Medical College, Zhongshan , Guangdong 528415, China
2. Department of Gastroenterology, Xiaolan Clinical Institute of Shantou University Medical College, Zhongshan , Guangdong 528415, China
3. Department of Oncology, Xiaolan Clinical Institute of Shantou University Medical College, Zhongshan , Guangdong 528415, China
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Gastric ulcer;
Gastric cancer;
Inflammation-cancer transformation
- From:
Journal of Public Health and Preventive Medicine
2026;37(4):151-154
- CountryChina
- Language:Chinese
-
Abstract:
As one of the common chronic bacterial infections, Helicobacter pylori (Hp) infection is a key pathogenic factor of chronic gastritis, peptic ulcer and gastric cancer. In the formation of gastric ulcer, Hp virulence factors directly damage the gastric mucosal barrier, induce the local inflammation and immune response, interfere with the regulation of gastric acid secretion, and ultimately destroy the mucosal stability. In the occurrence of gastric cancer, Hp-driven chronic inflammation is the basis of inflammation-cancer transformation, and it induces the genomic instability and epigenetic changes by interfering with key signaling pathways in host cells, thereby promoting malignant transformation. This paper systematically reviews the related mechanisms of Hp-induced gastric ulcer and gastric cancer in recent years, holding great significance for the development of new intervention strategies and the precise prevention and treatment of gastric cancer.
