Research progress on novel serum and urine biomarkers in early diagnosis of diabetic nephropathy

VernacularTitle:新型血清与尿液生物标志物在糖尿病肾病早期诊断中的研究进展
Author: Hong CHEN ¹ ; Yue QI ²
Author Information

1. Outpatient Department Blood Collection, West China Hospital, Sichuan University, Chengdu , Sichuan 610041, China
2. Department of Nephrology, Chengdu Integrated TCM＆Western Medicine Hospital, Chengdu , Sichuan 610000, China
Publication Type:Journal Article
Keywords: Diabetic nephropathy; Serum biomarkers; Urinary biomarkers; Early diagnosis
From: Journal of Public Health and Preventive Medicine 2026;37(4):146-150
CountryChina
Language:Chinese
Abstract: Diabetic nephropathy (DN) is one of the main causes of chronic kidney disease and end-stage renal disease (ESRD) worldwide, especially in patients with type 2 diabetes mellitus (T2DM). Early diagnosis is crucial for slowing down the progression of DN and improving the prognosis of patients. Traditional diagnostic methods, such as measurement of urinary microalbumin (mALB) and estimated glomerular filtration rate (eGFR), often fail to detect early renal injury because structural renal injury may occur before albumin excretion. This study aims to optimize clinical diagnostic methods for DN, reduce patient risk of onset, and provide a theoretical basis for further exploration of diagnostic biomarkers of DN by evaluating the diagnostic value of multiple novel serum and urine biomarkers in the early detection of DN.