Correlation analysis of thyroid hormones with massive proteinuria in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-2483.2026.04.028
- VernacularTitle:2型糖尿病患者甲状腺激素与大量蛋白尿的相关性分析
- Author:
Yufei TIAN
1
;
Yi LI
1
;
Bohui GUO
1
;
Lin ZHOU
1
;
Wei YANG
1
Author Information
1. Department of Nephrology, 3201 Hospital, Hanzhong , Shaanxi 723000, China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Proteinuria;
Free triiodothyronine;
Free thyroxine;
Thyroid stimulating hormone
- From:
Journal of Public Health and Preventive Medicine
2026;37(4):134-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between thyroid hormones and massive proteinuria in patients with type 2 diabetes mellitus (T2DM). Methods A total of 308 patients with T2DM admitted to 3201 Hospital between June 2020 and June 2025 were selected as the observation group, and another 250 healthy individuals who underwent physical examinations during the same period served as the control group. The thyroid hormones levels [free triiodothyronine (FT3), thyroid stimulating hormone (TSH), and free thyroxine (FT4)] were measured and compared between the two groups. Based on whether 24-hour urinary protein quantification was ≥ 3.5 g, the patients in the observation group were divided into a massive proteinuria group and a non-massive proteinuria group. Multivariate logistic regression analysis was used to analyze the factors influencing the occurrence of massive proteinuria in T2DM patients. Pearson method was applied to analyze the relationship of thyroid hormone indicators with severity indicators of massive proteinuria. Results Compared with the control group and the non-massive proteinuria group, FT3 and FT4 in the massive proteinuria group were lower, while TSH was higher (P<0.05). Multivariate logistic regression analysis suggested that glycosylated hemoglobin (OR=1.113, 95%CI: 1.045-1.185), TSH (OR=1.123, 95%CI: 1.006-1.253), eGFR (OR=0.894, 95%CI: 0.822-0.973), and FT3 (OR=0.898, 95%CI: 0.828-0.973) were related factors for the occurrence of massive proteinuria in T2DM patients (P<0.05). Pearson correlation analysis revealed that FT3 and FT4 levels in T2DM patients were significantly negatively correlated with 24-hour urinary protein quantification (r=-0.514, -0.502), while the level of TSH was positively correlated with 24-hour urinary protein quantification (r=0.486) (P<0.001). Conclusion In T2DM patients, low FT3 and eGFR levels and high TSH and glycosylated hemoglobin levels are related factors for the occurrence of massive proteinuria, and thyroid hormone levels are significantly associated with the severity of massive proteinuria.
