Clinical characteristics and influencing factors of patients with type 2 diabetes mellitus complicated with osteoporosis
10.3969/j.issn.1006-2483.2026.04.020
- VernacularTitle:2型糖尿病合并骨质疏松患者的临床特征及影响因素
- Author:
Lin ZHANG
1
;
Yunzhuo WANG
2
;
Tanrong ZHANG
1
Author Information
1. Endocrinology and Metabolism Department, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China
2. Clinical Medicine, the Second Clinical Medical School of Nanjing Medical University, Nanjing, Jiangsu 211166, China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Osteoporosis;
Clinical characteristics;
Logistic regression analysis
- From:
Journal of Public Health and Preventive Medicine
2026;37(4):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of type 2 diabetes mellitus (T2DM) complicated with osteoporosis (OP), and conduct logistic regression analysis to screen the influencing factors. Methods A total of 380 patients with T2DM admitted to the Second Affiliated Hospital of Xi'an Jiaotong University from January 2022 to December 2024 were selected. The patients were divided into the OP group (84 cases) and the non-OP group (296 cases) based on bone mineral density. Clinical data and biochemical indicators were compared between the two groups, and logistic regression analysis was used to identify the influencing factors of T2DM complicated with OP. Results The proportions of females and patients with smoking history were higher in the OP group than those in the non-OP group (P<0.05). Glycated hemoglobin (HbA1c) level in the OP group was higher than that in the non-OP group, and 25-hydroxyvitamin D3 (25(OH)D3) level was lower than that in the non-OP group (P<0.05). Multivariate logistic regression analysis showed that female gender, smoking, high HbA1c level, and low 25 (OH) D3 level were risk factors for T2DM complicated with OP. Conclusion Type 2 diabetes patients with osteoporosis have the clinical characteristics of a high proportion of women and a high proportion of smoking history, and they exhibit higher HbA1c levels and lower 25(OH)D3 levels. Female gender, smoking, high HbA1c level, and low 25(OH)D3 level are risk factors for OP in patients with T2DM.
