Relationship between heart failure and blood pressure variability in patients with hypertension and unstable angina pectoris
10.3969/j.issn.1006-2483.2026.04.017
- VernacularTitle:高血压合并不稳定型心绞痛患者心力衰竭发生与血压变异性的关系
- Author:
Jing ZHANG
1
;
Lingyan SU
1
;
Hongyan CUI
1
Author Information
1. Department of Cardiovascular Internal Medicine, Nantong Third People's Hospital, Nantong, Jiangsu 226000, China
- Publication Type:Journal Article
- Keywords:
Hypertension;
Unstable angina pectoris;
Heart failure;
Blood pressure variability;
Cox regression
- From:
Journal of Public Health and Preventive Medicine
2026;37(4):81-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between occurrence of heart failure (HF) and blood pressure variability in patients with hypertension complicated with unstable angina pectoris (UA). Methods The data of 385 patients with hypertension and UA admitted to the Nantong Third People's Hospital from January 2022 to January 2024 were collected and analyzed. After discharge, the enrolled patients were followed up for 1 year via outpatient visits or telephone calls. The study endpoint was new-onset HF. The relationship of blood pressure variability with new-onset HF was analyzed. Results According to the clinical risk stratification of UA, the blood pressure variability in the high-risk group was higher than that in the low-risk group and the medium-risk group (P<0.05). There were 46 cases (11.94%) of new-onset HF among 385 UA patients with hypertension. After adjusting for confounding factors, the risk of new-onset HF in UA patients with hypertension was increased with the increases of 24 h systolic blood pressure standard deviation (24 h SSD) [HR (95% CI)=4.20 (2.33-14.79)] and nighttime systolic blood pressure standard deviation (nSSD) [HR (95% CI)=1.94 (1.53-2.46)] (P<0.05). Receiver operating characteristic (ROC) curve indicated that the AUCs of Model 1 and Model 2 in predicting new-onset HF were 0.776 and 0.869, and 95% CI values were 0.707-0.844 and 0.820-0.918, respectively. The AUC of Model 2 was higher than that of Model 1 (Z/P=3.734/<0.001). Conclusion For patients with hypertension complicated with unstable angina pectoris, the blood pressure variability indicators at admission have high predictive value on new-onset heart failure.
